Document Detail

Determinants of parental decisions to abort for chromosome abnormalities.
MedLine Citation:
PMID:  2267225     Owner:  NLM     Status:  MEDLINE    
Parental decisions concerning the continuation of pregnancy following prenatal detection of abnormal chromosomes were evaluated for 80 patients whose diagnosis and prenatal counselling were performed in our centre. Twenty-two anomalies were diagnosed by chorionic villus sampling (CVS) and 58 by amniocentesis. The severity of the chromosome anomaly and associated ultrasound findings in the first vs. second trimester were correlated with patients' decisions. No difference was found in the likelihood of parental decisions to interrupt or continue a pregnancy between CVS and amniocentesis for either the 'severe' or the 'questionable' group of chromosome anomalies. Ninety-three per cent of patients with severe prognosis and 27 per cent with questionable prognosis opted for pregnancy termination (p less than 0.0001). The association of ultrasound anomalies and termination was highly significant (p less than 0.001). The severity of the chromosome anomaly, and, to a lesser extent, the visualization of anomalies on ultrasound were the major determinants of parental decisions to terminate the pregnancy. The diagnosis of an anomaly in the first trimester was no more likely ito lead to a termination of pregnancy than in the second trimester.
A Drugan; A Greb; M P Johnson; E L Krivchenia; W R Uhlmann; K S Moghissi; M I Evans
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  10     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1991-02-08     Completed Date:  1991-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  483-90     Citation Subset:  E; IM    
Department of Obstetrics/Gynecology, Hutzel Hospital/Wayne State University, Detroit, MI 48201.
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MeSH Terms
Abortion, Therapeutic / psychology*
Chorionic Villi Sampling
Chromosome Aberrations
Chromosome Disorders
Decision Making*
Fetus / abnormalities
Maternal Age
Parents / psychology*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prenatal Diagnosis*
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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