Document Detail

Determinants of left ventricular hypertrophy and its progression in high-flux haemodialysis.
MedLine Citation:
PMID:  12601259     Owner:  NLM     Status:  MEDLINE    
AIM: To identify factors contributing to the development and progression of left ventricular hypertrophy (LVH) in patients on high-flux haemodialysis. METHOD: Fifty patients without clinical cardiac disease underwent baseline echocardiography, related measurements and follow-up studies 6-12 months later. RESULTS: Residual urea clearance was lower (0.7 +/- 1.1 vs. 2.2 +/- 2.4 ml/min; p = 0.034) while systolic blood pressure (162 +/- 21 vs. 147 +/- 11 mm Hg; p = 0.003), duration of dialysis dependence (38 +/- 37 vs. 17 +/- 13 months; p = 0.004) and interdialytic weight gain (1.98 + 0.84 vs. 1.32 + 1.08 kg; p = 0.026) were higher in those with LVH. Parathyroid hormone changed less in those whose LVH regressed (186 +/- 89 vs. 303 +/- 280 pg/ml; p = 0.032). Regression did not occur when parathyroid hormone was >300 pg/ml. ACE gene polymorphism did not affect LVH development or progression. CONCLUSION: Systolic hypertension, duration of dialysis dependence and high interdialytic weight gains promote LVH. Hyperparathyroidism retards LVH regression.
Chiew H Kong; Ken Farrington
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood purification     Volume:  21     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  2003  
Date Detail:
Created Date:  2003-02-25     Completed Date:  2003-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Renal Unit, Lister Hospital, Stevenage, UK.
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MeSH Terms
Aged, 80 and over
Disease Progression
Follow-Up Studies
Hyperparathyroidism / blood,  complications
Hypertension / epidemiology
Hypertrophy, Left Ventricular / etiology*,  physiopathology,  ultrasonography
Kidney Failure, Chronic / complications,  therapy*
Middle Aged
Parathyroid Hormone / blood
Peptidyl-Dipeptidase A / genetics
Polymorphism, Genetic
Renal Dialysis / adverse effects*,  methods
Risk Factors
Weight Gain
Reg. No./Substance:
0/Parathyroid Hormone; EC A

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