Document Detail

Determinants of kidney function in Swedish families: role of heritable factors.
MedLine Citation:
PMID:  18698211     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the modification of diet in renal disease-glomerular filtration rate. After full adjustment, the heritability values were 51% for the measured creatinine clearance (P < 0.01), 58% for the estimated Cockcroft-Gault-creatinine clearance (P < 0.001), 40% for the estimated by the modification of diet in renal disease-glomerular filtration rate (P < 0.001), but 8% (P = 0.34) for serum creatinine.Our data confirm that kidney function is partially under genetic control and that genetic variants of importance for this trait could be mapped. The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation.
Cristiano Fava; Martina Montagnana; Philippe Burri; Peter Almgren; Pietro Minuz; U Lennart Hulthén; Olle Melander
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  26     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1773-9     Citation Subset:  IM    
Department of Clinical Sciences, Lund University, University Hospital of Malmö, Malmö, Sweden.
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MeSH Terms
Blood Pressure
Circadian Rhythm
Creatinine / blood
Genetic Predisposition to Disease / epidemiology
Glomerular Filtration Rate
Hypertension, Renal / epidemiology*,  genetics*,  physiopathology
Kidney / physiology*
Kidney Function Tests*
Linear Models
Middle Aged
Multivariate Analysis
Risk Factors
Sweden / epidemiology
Reg. No./Substance:

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