| Determinants of inter-individual cholesterol level variation in an unbiased young male sample. | |
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MedLine Citation:
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PMID: 18491242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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QUESTION UNDER STUDY: Affected by individual life style, the total cholesterol serum level is a major morbidity and mortality risk factor for atherosclerotic cardiovascular disease (CVD). We present total cholesterol values and their possible aetiological factors of young Swiss conscripts. Particularly, we study varying impact of these factors depending on different levels of individual cholesterol. METHODS: Male conscripts (n = 19,272) of the 2005 census of the conscripts have been examined, reflecting ca. 59% of a total Swiss male birth cohort. Quantile regression allows us to analyse responses of arbitrary quantiles with respect to variables of interest. RESULTS: Eleven percent of all conscripts show clinically important increased total cholesterol levels. There is a major association of high individual cholesterol level with French regional language. The largest socio-economic subsample--agricultural and construction workers--show significantly higher individual cholesterol levels than employees in the industry sector and students, respectively. CONCLUSIONS: We were able to find that culture, as indicated by the mother tongue, and socioeconomic status as indicated by profession/vocation, influence individual total cholesterol levels while climate as indicated by altitude does not have an influence on cholesterol levels. Such a broad screening programme offers a unique opportunity to target persons at high-risk for CVD morbidity and mortality already early in life. |
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Authors:
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Frank Jakobus Rühli; Maciej Henneberg; Dominik J Schaer; Alexander Imhof; Boris Schleiffenbaum; Ulrich Woitek |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Swiss medical weekly Volume: 138 ISSN: 1424-7860 ISO Abbreviation: Swiss Med Wkly Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-20 Completed Date: 2008-10-07 Revised Date: 2011-02-15 |
Medline Journal Info:
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Nlm Unique ID: 100970884 Medline TA: Swiss Med Wkly Country: Switzerland |
Other Details:
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Languages: eng Pagination: 286-91 Citation Subset: IM |
Affiliation:
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Institute of Anatomy, University of Zurich, Zurich, Switzerland. frank.ruhli@anatom.uzh.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atherosclerosis / blood Cholesterol / blood* Cohort Studies Humans Hypercholesterolemia / blood* Life Style* Male Military Personnel* Multilingualism Reference Values Risk Factors Social Environment Socioeconomic Factors Switzerland |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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