Document Detail


Determinants of the human infant intestinal microbiota after introduction of first complementary foods in five European centres.
MedLine Citation:
PMID:  21330436     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although it is well established that early infant feeding has a major influence on the establishment of the gut microbiota, very little is understood about how introduction of first solid food influences the colonisation process. This study aimed to determine the impact of weaning on faecal microbiota composition of infants from 5 European countries (Sweden, Scotland, Germany, Italy and Spain) with different lifestyle characteristics and infant feeding practices. Faecal samples were collected from 605 infants approximately 4 weeks after introduction of first solid foods and results compared with the same infants before weaning (6 weeks of age) to investigate the association with determining factors such as geographic origin, mode of delivery, previous feeding method, and age of weaning. Samples were analysed by fluorescent in situ hybridisation (FISH) and flow cytometry using a panel of 10 rRNA targeted group- and species-specific oligonucleotide probes. The Bifidobacterium genus (36.5% average proportion of total detectable bacteria), Clostridium coccoides group (14%) and Bacteroides (13.6%) were predominant after weaning. Similar to pre weaning, Northern-European countries were associated with higher bifidobacteria in infant gut microbiota while higher Bacteroides and lactobacilli characterized Southern countries. As before weaning, the initial feeding method influenced the C. leptum group and C. difficile + C. perfringens species, and bifidobacteria still dominated the faeces of initially breast-fed infants. Formula-fed babies presented significantly higher proportions of Bacteroides and Clostridium coccoides group. The mode of birth influenced changes in proportions of Bacteroides and Atopobium. Although there were significant differences in mean weaning age between countries this was not related to populations of bifidobacteria or bacteroides. Thus although the faecal microbiota of infants after first complementary foods was different to that before weaning commenced, many of the initial influences on microbiota composition were still evident.
Authors:
Matteo Fallani; Sergio Amarri; Agneta Uusijarvi; Rudiger Adam; Sheila Khanna; Marga Aguilera; Angel Gil; Jose M Vieites; Elisabeth Norin; David Young; Jane A Scott; Joel Dore; Christine Edwards; The Infabio Team
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  -     ISSN:  1465-2080     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Hospitex Diagnostics srl;
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