| Determinants of homocysteine levels in Ivorian rural population. | |
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MedLine Citation:
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PMID: 20533218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, homocysteine (Hcy) and vitamin B status were determined in healthy subjects living in two opposite regions of the Ivory Coast. Fifty-six subjects from a coastal region (Bodou) having a fish-based diet and 56 subjects from a mountainous area (Glanle) having a vegetarian diet were tested to sample Hcy, folate, vitamin B12, creatinine, and lipid levels, as well as inflammation and nutritional parameters. An increased prevalence of Hcy > or = 15 micromol/L was observed, reaching 60 % of all subjects. The Bodou group exhibited significantly higher Hcy levels than the Glanle group [20.1 (9.7 - 41.4) vs. 13.6 (5.5 - 48.7) micromol/L, p<0.0001], despite higher vitamin B12 levels [593 (163 - 1860) vs. 234 (83 - 585) pg/mL, p<0.0001]. Although folate levels were lower in subjects from Bodou compared to Glanle [3.2 (2.0 - 7.3) vs. 6.0 (1.9 - 18.2) ng/mL, p<0.0001], there was no significant relationship with Hcy levels in any groups. Interestingly, there were significantly higher creatinine levels in subjects from Bodou compared to Glanle and a significant positive relationship with Hcy levels was evident in each group. In conclusion, Hcy levels in an Ivorian population having a fish-based diet appeared significantly higher compared to subjects having a vegetarian diet. However, folate and vitamin B12 status did not emerge as the major determinants of this difference; a stronger relationship was observed with creatinine levels. |
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Authors:
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Georges Tiahou; Anne-Marie Dupuy; Isabelle Jaussent; Daniel Sees; Jean-Paul Cristol; Stephanie Badiou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Volume: 79 ISSN: 0300-9831 ISO Abbreviation: Int J Vitam Nutr Res Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273304 Medline TA: Int J Vitam Nutr Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 319-27 Citation Subset: IM |
Affiliation:
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Laboratoire de Biochimie Médicale, Université Bouake, Bouake, Cote d'Ivoire. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged C-Reactive Protein / metabolism Cholesterol / blood Cote d'Ivoire Creatinine / blood Female Folic Acid / blood* Food Habits* Glomerular Filtration Rate / physiology Homocysteine / blood* Humans Male Middle Aged Rural Population Serum Albumin / metabolism Statistics, Nonparametric Triglycerides / blood Vitamin B 12 / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 0/Triglycerides; 454-28-4/Homocysteine; 57-88-5/Cholesterol; 59-30-3/Folic Acid; 60-27-5/Creatinine; 68-19-9/Vitamin B 12; 9007-41-4/C-Reactive Protein |
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