Document Detail

Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.
MedLine Citation:
PMID:  7372646     Owner:  NLM     Status:  MEDLINE    
The uptake and metabolism of lymphatic large chylomicrons from fat-fed rats, lymphatic small chylomicrons from glucose-fed rats, and hepatic very low density lipoproteins from perfusates of isolated livers, and of remnants produced from these lipoproteins in functionally eviscerated rats were studied in the isolated perfused rat liver. All lipoproteins were labeled isotopically in their cholesteryl ester and triglyceride moieties. Uptake of the labeled lipids or large chylomicrons was slow and limited, but these lipids in small chylomicrons and hepatic very low density lipoproteins were taken up and metabolized progressively and at equal rates. Incubation with very low density lipoprotein-free plasma increased the content of C apolipoproteins in small chylomicrons and hepatic very low density lipoproteins and greatly retarded the hepatic uptake of their labeled lipids. In remnants from all sources, which are depleted of C apolipoproteins but not of apolipoprotein E, the labeled lipids were rapidly taken up and metabolized. Neither extensive hydrolysis of core triglycerides nor the production of monoglycerides was required for this rapid hepatic uptake. These results are consistent with the hypothesis that one or more of the C apolipoproteins opposes and apolipoprotein E promotes recognition of triglyceride-rich lipoproteins by a hepatic receptor.
E Windler; Y Chao; R J Havel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  255     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5475-80     Citation Subset:  IM    
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MeSH Terms
Carbon Radioisotopes
Cholesterol Esters / analysis
Chylomicrons / metabolism
Dietary Carbohydrates
Dietary Fats
Lipoproteins / metabolism*
Lipoproteins, VLDL / metabolism
Liver / metabolism*
Triglycerides / metabolism
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Cholesterol Esters; 0/Chylomicrons; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipoproteins; 0/Lipoproteins, VLDL; 0/Triglycerides; 10028-17-8/Tritium

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