Document Detail

Determinants of heart rate recovery in coronary artery disease patients with and without type 2 diabetes.
MedLine Citation:
PMID:  23006231     Owner:  NLM     Status:  Publisher    
Cardiovascular autonomic dysfunction, which is a common complication of diabetes, is associated with increased mortality in patients with coronary artery disease (CAD). However, the reasons of autonomic dysfunction in CAD patients with or without diabetes are not well known. We examine the association between heart rate recovery (HRR) and other potential factors among CAD patients with and without type 2 diabetes (T2D). Correlations between HRR 60s after exercise (HRR(60)), characteristics, laboratory and echocardiographic variables, exercise capacity and physical activity were assessed in 50 CAD patients with T2D and 55 patients with CAD alone. HRR(60) had the closest univariate correlation with physical activity and exercise capacity in patients with T2D (r=0.38, p=0.006 and r=0.37, p=0.008, respectively). Age, exercise capacity and high-density lipoprotein cholesterol level explained 30% of the HRR(60) in patients with T2D (p=0.001), while the high intensity physical activity was the only predictor of HRR(60) in CAD patients (12%, p=0.010). HRR(60) was reduced in patients with T2D as compared with those without (34±9 vs. 39±9bpm, p=0.005), but the difference was no longer significant after adjustments for physical activity, exercise capacity, body mass index and the use of calcium antagonists and nitrates (p=0.273). In conclusion, blunted HRR is more common among CAD patients with T2D than in those without, and this is more closely related to physical activity and obesity than to the duration of T2D or associated co-morbidities.
Jaana J Karjalainen; Antti M Kiviniemi; Arto J Hautala; Olli-Pekka Piira; E Samuli Lepojärvi; Timo H Mäkikallio; Heikki V Huikuri; Mikko P Tulppo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-21
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  -     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Finland; Department of Exercise and Medical Physiology, Verve Research, Oulu, Finland.
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