| Determinants of glomerular ultrafiltration in cats. | |
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MedLine Citation:
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PMID: 8323069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the determinants of glomerular ultrafiltration, renal micropuncture studies were performed in 9 cats. Mean single nephron glomerular filtration rate (SNGFR), directly measured in outer cortical nephrons, was 29.4 +/- 3.0 nl/min. This was similar to the estimated value for SNGFR (31.3 +/- 4.6 nl/min) obtained by dividing left kidney total glomerular filtration rate (1.41 +/- 0.12 ml/min/kg of body weight) by left glomerular count (175,200 +/- 13,600 glomeruli/kidney). In micropuncture studies performed at mean renal perfusion pressure of 101.3 +/- 1.0 mm of Hg, the glomerular capillary hydrostatic pressure was 58.0 +/- 1.4 mm of Hg. The glomerular transcapillary hydrostatic pressure gradient (40.0 +/- 1.8 mm of Hg) exceeded colloid osmotic pressure at the efferent end of the glomerular capillaries (28.4 +/- 2.1 mm of Hg) in all cats studied, indicating existence of positive effective filtration pressure throughout the glomerular capillary bed. These results indicate that glomerular capillary pressure is sufficiently high to prevent forces from reaching filtration pressure equilibrium in feline outer cortical nephrons. Thus, the value of SNGFR in feline nephrons depends on the glomerular transcapillary hydrostatic pressure gradient and the glomerular ultrafiltration coefficient. |
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Authors:
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S A Brown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 54 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-08-03 Completed Date: 1993-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 970-5 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats / physiology* Glomerular Filtration Rate / physiology, veterinary* Kidney Glomerulus / physiology* Models, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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