Document Detail

Determinants of erectile dysfunction in type 2 diabetes.
MedLine Citation:
PMID:  20147958     Owner:  NLM     Status:  MEDLINE    
This study was designed to evaluate the prevalence and correlates of ED in a population of diabetic men. Consecutive patients with type 2 diabetes were recruited among outpatients regularly attending Diabetes Clinics. Inclusion criteria for the initial selection of patients were a diagnosis of type 2 diabetes for at least 6 months but less than 10 years, age 35-70 years, body mass index (BMI) of 24 or higher, HbA1c of 6.5% or higher: a total of 555 (90.8%) of the 611 men were analyzed in this study. ED was assessed by the IIEF-5 instrument. Approximately, 6 in 10 men in our sample of diabetic men had varying degrees of erectile dysfunction: mild 9%, mild to moderate 11.2%, moderate 16.9% and severe 22.9%. The prevalence of severe ED increased with age. Higher hemoglobin A1c (HbA1c) levels were associated with ED; similarly, the presence of metabolic syndrome, hypertension, atherogenic dyslipidemia (low levels of HDL-cholesterol and high levels of triglycerides) and depression was associated with ED. Physical activity was protective of ED; men with higher levels of physical activity were 10% less likely to have ED as compared with those with the lowest level. In conclusion, among subjects with type 2 diabetes glycemic control and other metabolic covariates were associated with ED risk, whereas higher level of physical activity was protective. These results encourage the implementation of current medical guidelines that place intensive lifestyle changes as the first step of the management of type 2 diabetes.
F Giugliano; M Maiorino; G Bellastella; M Gicchino; D Giugliano; K Esposito
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Publication Detail:
Type:  Journal Article     Date:  2010-02-11
Journal Detail:
Title:  International journal of impotence research     Volume:  22     ISSN:  1476-5489     ISO Abbreviation:  Int. J. Impot. Res.     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007383     Medline TA:  Int J Impot Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Division of Urology, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy.
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MeSH Terms
Age Factors
Body Mass Index
Depression / complications
Diabetes Mellitus, Type 2 / complications*
Erectile Dysfunction / complications,  epidemiology*,  physiopathology
Hemoglobin A, Glycosylated / analysis
Hyperlipidemias / complications
Hypertension / complications
Life Style
Metabolic Syndrome X / complications
Middle Aged
Reg. No./Substance:
0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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