| Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters. | |
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MedLine Citation:
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PMID: 21521255 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Polycystic ovary syndrome (PCOS) is associated with dyslipidaemia and obesity. It is not clear whether the dyslipidaemia of PCOS is due to PCOS itself, obesity, or a combination of both. Our objective is to assess the importance of familial dyslipidaemia in PCOS by comparing fasting lipids between probands and their (affected and non-affected) sisters. Design: Retrospective dataset analyses Patients: Family study; 157 probands, 214 sisters and 76 control women (normal ovaries and regular cycles). All probands had PCOS, defined by symptoms of anovulation and/or hyperandrogenism with polycystic ovaries on ultrasound. Affected or unaffected status of sisters was defined by ovarian morphology. Measurements: Serum concentrations of triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. Results: Triglyceride levels and BMI were higher and HDL cholesterol levels lower in the probands than affected sisters, unaffected sisters, and controls. These differences in lipid profiles between the groups disappeared after adjustment for BMI. No differences in lipids were seen between affected and unaffected sisters. Conclusions: These data are consistent with heritability of lipid levels in sisters but strongly suggest that the predominant influence in the manifestation of dyslipidaemia in PCOS is body weight. |
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Authors:
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Jalini Joharatnam; Thomas M Barber; Lisa Webber; Gerard S Conway; Mark McCarthy; Stephen Franks |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-17 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Imperial College London - Reproductive Endocrinology 5th Floor IRDB Hammersmith Hospital Du Cane Rd, London W12 ONN United Kingdom University of Oxford - Diabetes and Endocrinology Oxford United Kingdom Imperial College NHS Healthcare Trust - Obstetrics and Gynaecology London United Kingdom University College Hospital - Reproductive Endocrinology London United Kingdom University of Oxford - Diabetes and Endocrinology Oxford United Kingdom Imperial College London - Reproductive Endocrinology London United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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