Document Detail

Determinants of coronary effects of atrial natriuretic factor in dogs.
MedLine Citation:
PMID:  1425857     Owner:  NLM     Status:  MEDLINE    
The direct vascular action of atrial natriuretic factor (ANF) is unclear. In coronary vasculature, vasodilation has been reported as well as vasoconstriction. Doses of ANF, baseline plasma ANF levels and interference with the renin-angiotensin system might account for the controversy. We tried to further analyse determinants of the effect of ANF on coronary blood flow in anaesthetized dogs. The chest was opened and the left anterior descending coronary artery cannulated and perfused at constant normal (= 76 +/- 5 mmHg, n = 10) or reduced (= 37 +/- 3 mmHg, n = 10) pressure from the femoral arteries. At normal coronary perfusion pressure, ANF (1 ng kg-1 i.c.) reduced coronary flow from 30.7 +/- 4.2 to 26.9 +/- 4.0 ml min-1 (P less than 0.05). This effect was no longer significant at reduced coronary perfusion pressure (4.9 +/- 0.8 vs. 4.6 +/- 0.7 ml min-1). ANF (1 ng kg-1 i.c.) reduced coronary blood flow in correlation with baseline plasma ANF levels (r = 0.77, P less than 0.001). However the large variability of the constrictor effect of ANF in the rather small range of baseline plasma ANF, weakens the importance of this result and suggests other additional determinants. ANF (100 ng kg-1 i.c.) significantly increased coronary blood flow by 16-23% (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
G Ertl; B Bauer; P Gaudron; M Kolb; K Kochsiek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  22     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  516-22     Citation Subset:  IM    
Medizinische Klinik, Universität Würzburg, Germany.
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MeSH Terms
Atrial Natriuretic Factor / pharmacology*
Blood Pressure / drug effects
Captopril / pharmacology
Coronary Circulation / drug effects*
Coronary Vessels / drug effects,  physiology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Muscle, Smooth, Vascular / drug effects,  physiology
Reference Values
Saralasin / pharmacology
Reg. No./Substance:
34273-10-4/Saralasin; 62571-86-2/Captopril; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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