| Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. | |
| | |
MedLine Citation:
|
PMID: 22219336 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Intestinal barrier dysfunction is a main feature of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Leak flux diarrhoea and a facilitated uptake of noxious antigens are the two consequences resulting from an impaired epithelial barrier. Barrier perturbations in IBD comprise alterations in epithelial tight junctions (TJ), i.e. a reduced number of horizontal TJ strands and an altered TJ protein expression and subcellular distribution. Moreover, increased incidence of apoptotic events as well as erosions and ulcerations can add to that leakiness. These barrier defects are attributed to enhanced activity of pro-inflammatory cytokines like TNFα, INFγ, IL-1β, and IL-13, which are highly expressed in the chronically inflamed intestine. Although the aetiology of IBD is far from being clear, chronic inflammation is believed to result from an inadequate immune response as a consequence of genetic predisposition as well as changes in, and altered responses to, the intestinal microbiota. On the other hand, an insufficient mucosal response to bacterial stimuli results in an insufficient immune response towards intestinal pathogens. However, detailed characterisation of barrier defects offers the opportunity to consider and test therapeutic interventions. Beside cytokine antagonists, different plant compounds and probiotics have been shown to stabilise the barrier function by affecting TJ protein expression and distribution. |
| | |
Authors:
|
Nina A Hering; Michael Fromm; Jörg-Dieter Schulzke |
Related Documents
:
|
10421776 - An alternate pathway for type 1 t cell differentiation. 1445496 - Interferon-gamma suppresses pdgf production from thp-1 cells and blood monocyte-derived... 12682726 - Regulatory cytokine production stimulated by dna vaccination against an altered form of... 1971296 - T cell subsets and ifn-gamma production in resistance to systemic candidosis in immuniz... 18362516 - Apoptosis inhibition by bcl-2 gives way to autophagy in glucocorticoid-treated lymphocy... 11222356 - Fas-l up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-4 |
Journal Detail:
|
Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Deptartment of Gastroenterology, Division of Nutritional Medicine, Charité; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep ap...
Next Document: Cortical basket cell dysfunction in schizophrenia.