| Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials. | |
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MedLine Citation:
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PMID: 22753785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of novel biomaterials able to control cell activities and direct their fate is warranted for engineering functional biological tissues, advanced cell culture systems, single-cell diagnosis as well as for cell sorting and differentiation. It is well established that crosstalk at the cell-material interface occurs and this has a profound influence on cell behaviour. However, the complete deciphering of the cell-material communication code is still far away. A variety of material surface properties have been reported to affect the strength and the nature of the cell-material interactions, including biological cues, topography and mechanical properties. Novel experimental evidence bears out the hypothesis that these three different signals participate in the same material-cytoskeleton crosstalk pathway via adhesion plaque formation dynamics. In this review, we present the relevant findings on material-induced cell response along with the description of cell behaviour when exposed to arrays of signals-biochemical, topographical and mechanical. Finally, with the aid of literature data, we attempt to draw unifying elements of the material-cytoskeleton-cell fate chain. |
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Authors:
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Maurizio Ventre; Filippo Causa; Paolo A Netti |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-06-29 |
Journal Detail:
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Title: Journal of the Royal Society, Interface / the Royal Society Volume: 9 ISSN: 1742-5662 ISO Abbreviation: J R Soc Interface Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-26 Completed Date: 2012-11-30 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101217269 Medline TA: J R Soc Interface Country: England |
Other Details:
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Languages: eng Pagination: 2017-32 Citation Subset: IM |
Affiliation:
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Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia and Interdisciplinary Research Center on Biomaterials, University of Naples Federico II, Napoli, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry* Cell Adhesion Cell Culture Techniques Cytoskeleton / metabolism* Humans Mechanotransduction, Cellular* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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