Document Detail


Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials.
MedLine Citation:
PMID:  22753785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of novel biomaterials able to control cell activities and direct their fate is warranted for engineering functional biological tissues, advanced cell culture systems, single-cell diagnosis as well as for cell sorting and differentiation. It is well established that crosstalk at the cell-material interface occurs and this has a profound influence on cell behaviour. However, the complete deciphering of the cell-material communication code is still far away. A variety of material surface properties have been reported to affect the strength and the nature of the cell-material interactions, including biological cues, topography and mechanical properties. Novel experimental evidence bears out the hypothesis that these three different signals participate in the same material-cytoskeleton crosstalk pathway via adhesion plaque formation dynamics. In this review, we present the relevant findings on material-induced cell response along with the description of cell behaviour when exposed to arrays of signals-biochemical, topographical and mechanical. Finally, with the aid of literature data, we attempt to draw unifying elements of the material-cytoskeleton-cell fate chain.
Authors:
Maurizio Ventre; Filippo Causa; Paolo A Netti
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-06-29
Journal Detail:
Title:  Journal of the Royal Society, Interface / the Royal Society     Volume:  9     ISSN:  1742-5662     ISO Abbreviation:  J R Soc Interface     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-11-30     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101217269     Medline TA:  J R Soc Interface     Country:  England    
Other Details:
Languages:  eng     Pagination:  2017-32     Citation Subset:  IM    
Affiliation:
Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia and Interdisciplinary Research Center on Biomaterials, University of Naples Federico II, Napoli, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / chemistry*
Cell Adhesion
Cell Culture Techniques
Cytoskeleton / metabolism*
Humans
Mechanotransduction, Cellular*
Chemical
Reg. No./Substance:
0/Biocompatible Materials
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