| Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis. | |
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MedLine Citation:
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PMID: 16793953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the present study was to clarify the relationship between GH deficiency (GHD) and some cardiovascular risk factors and to analyse the effect of GH replacement therapy in a large number of patients over a prolonged period of time. DESIGN: Data for analysis were retrieved from KIMS (Pfizer International Metabolic Database). Serum concentrations of total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides were obtained from 2589 patients at baseline and from 1206 patients after 1 and 2 years of GH replacement therapy. Body mass index (BMI), waist and hip, resting blood pressure and body composition were also measured. RESULTS: At baseline, the unfavourable effects of GHD were most obvious in the lipid profile demonstrating elevated mean total and LDL-cholesterol, in the increased waist circumference and the elevated BMI. The cholesterol concentration, BMI and body composition were significantly adversely affected by a number of factors, including age, sex and the use of anti-epileptic drugs. The therapeutic effect of GH was essentially uniform across the whole population. GH replacement reduced significantly the mean total and LDL-cholesterol, the waist circumference and the fat mass and was maintained during 2 years. CONCLUSIONS: This analysis of a large number of patients confirmed that GHD adults present with an increased cardiovascular risk. The sustained improvement of the adverse lipid profile and body composition suggests that GH replacement therapy may reduce the risk of cardiovascular disease and the premature mortality seen in hypopituitary patients with untreated GHD. |
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Authors:
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Roger Abs; Ulla Feldt-Rasmussen; Anders F Mattsson; John P Monson; Bengt-Ake Bengtsson; Miklós I Góth; Patrick Wilton; Maria Koltowska-Häggström |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 155 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-23 Completed Date: 2006-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 79-90 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, University Hospital, Antwerp, Belgium. rogers.abs@uza.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Age of Onset Aged Blood Pressure / physiology Body Composition / physiology Body Mass Index Cardiovascular Diseases / blood, epidemiology*, etiology* Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Databases, Factual Female Growth Hormone / therapeutic use Hormone Replacement Therapy Human Growth Hormone / deficiency* Humans Hypopituitarism / complications*, drug therapy Insulin-Like Growth Factor I / metabolism Male Middle Aged Regression Analysis Risk Factors Sex Factors Triglycerides / blood Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 12629-01-5/Human Growth Hormone; 57-88-5/Cholesterol; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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