| Determinants of cardiac fibrosis in experimental hypermineralocorticoid states. | |
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MedLine Citation:
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PMID: 7485478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uninephrectomized rats maintained on 1.0% NaCl to drink and infused with aldosterone (0.75 microgram/h) for 8 wk have previously been shown to develop hypertension, cardiac hypertrophy, and cardiac fibrosis. In the present study we have shown that K+ supplementation (1.0% NaCl plus 0.4% KCl drinking solution) alters neither the interstitial nor the perivascular fibrotic response to mineralocorticoid treatment. Second, rats receiving 0.75 microgram/h 9 alpha-fluorocortisol, a mineralocorticoid and glucocorticoid agonist, respond with hypertension and cardiac fibrosis without cardiac hypertrophy. Finally, intracerebroventricular infusion of the mineralocorticoid receptor antagonist RU-28318 blocks blood pressure elevation, but not cardiac hypertrophy or fibrosis, when aldosterone is coinfused peripherally. We conclude that the myocardial fibrosis observed in response to chronic mineralocorticoid elevation and salt loading is a humorally mediated event independent of hypokalemia, hypertension, and cardiac hypertrophy. It remains to be determined whether the fibrosis observed in the presence of excess salt represents a direct (e.g., cardiac) effect of mineralocorticoid hormones or one mediated via a primary action on classical epithelial aldosterone target tissues (e.g., kidney). |
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Authors:
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M Young; G Head; J Funder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 269 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E657-62 Citation Subset: IM |
Affiliation:
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Baker Medical Research Institute, Prahran, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Aldosterone / pharmacology Aldosterone Antagonists / pharmacology Animals Desoxycorticosterone / pharmacology* Drug Combinations Fibrosis Fludrocortisone / pharmacology Heart / drug effects* Hormone Antagonists / pharmacology Male Mifepristone / pharmacology Myocardium / pathology* Nephrectomy Potassium / blood Rats Rats, Sprague-Dawley Spironolactone / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Drug Combinations; 0/Hormone Antagonists; 127-31-1/Fludrocortisone; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 64-85-7/Desoxycorticosterone; 7440-09-7/Potassium; 76676-34-1/RU 28318; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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