| Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study. | |
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MedLine Citation:
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PMID: 21975210 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Abnormal high cerebral iron deposition may be implicated in chronic neurologic disorders, including multiple sclerosis (MS). R2* relaxometry has been recently validated in a postmortem study to indicate brain iron accumulation in a quantitative manner. We used this technique to assess brain iron levels in different stages of MS and healthy controls (HC) and determined their relation with demographic, clinical, neuropsychological, and other imaging variables. METHODS: We studied 113 consecutive patients (35 clinically isolated syndrome [CIS], 78 MS) and 35 HC with 3 T MRI and clinical and neuropsychological examination. Iron deposition in subcortical gray matter structures was assessed by automated, regional calculation of R2* rates. RESULTS: Basal ganglia (BG) R2* levels were significantly increased in MS compared to CIS (p < 0.001) and HC (p < 0.005). They were correlated with age (r = 0.5, p < 0.001), disease duration (r = 0.5, p < 0.001), Expanded Disability Status Scale (r = 0.3, p < 0.005), and the z values of mental processing speed (r = -0.3, p < 0.01). Stepwise linear regression analysis revealed gray matter atrophy as the strongest independent predictor of BG R2* levels (p < 0.001), followed by age (p < 0.001) and T2 lesion load (p < 0.005). CONCLUSION: BG iron accumulation in MS occurs with advancing disease and is related to the extent of morphologic brain damage, which argues for iron deposition as an epiphenomenon. The absence of increased iron levels in patients with CIS indicates that iron accumulation does not precede the development of MS. |
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Authors:
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M Khalil; C Langkammer; S Ropele; K Petrovic; M Wallner-Blazek; M Loitfelder; M Jehna; G Bachmaier; R Schmidt; C Enzinger; S Fuchs; F Fazekas |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-10-05 |
Journal Detail:
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Title: Neurology Volume: 77 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-01 Completed Date: 2011-12-13 Revised Date: 2012-01-06 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1691-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Medical University of Graz, Graz, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / anatomy & histology, metabolism*, pathology* Female Humans Iron / metabolism* Magnetic Resonance Imaging / methods* Male Middle Aged Multiple Sclerosis / pathology*, physiopathology* Neuropsychological Tests Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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J 2992-B09//Austrian Science Fund FWF |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
| Comments/Corrections | |
Comment In:
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Neurology. 2011 Nov 1;77(18):1660-1
[PMID:
21975201
]
J Neurol. 2011 Dec;258(12):2302-4 [PMID: 22124730 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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