| Determinants of augmentation index in young men: the ARYA study. | |
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MedLine Citation:
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PMID: 15606725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is an increasing interest in the augmentation index (AIx), the proportion of the central pulse pressure resulting from peripheral arterial wave reflection, which has been related to cardiovascular disease risk and mortality. Most of the data on the AIx have been collected in patients with established cardiovascular disease. In contrast, data in the young are scarce. However, as AIx might be used to evaluate cardiovascular disease risk already at an early age, we aimed to study determinants of AIx in a population of healthy young men. MATERIALS AND METHODS: Three hundred and thirty males (mean age of 28 years) of the Atherosclerosis Risk in Young Adults study (ARYA-study) were studied in this cross sectional, population-based study. Anthropometrics and risk factors for cardiovascular disease were determined and AIx was estimated by radial applanation tonometry. The data were analysed using linear regression models. RESULTS: Augmentation index was associated with age, height (inverse), heart rate (inverse) and mean arterial pressure (positive). After adjustment for these determinants, smoking (beta = 0.31%/pack years, 95% CI [0.06; 0.55]) and LDL-cholesterol (beta = 1.28%/(mmol L(-1)), 95% CI [0.04; 2.51]) were statistically significant related to AIx. CONCLUSIONS: This study among young adult males shows that smoking and LDL-cholesterol are positively related to AIx. These findings support the view that AIx may be used as a marker for early vascular damage and cardiovascular disease risk. |
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Authors:
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M J C A van Trijp; W J W Bos; C S P M Uiterwaal; A Oren; L E Vos; D E Grobbee; M L Bots |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical investigation Volume: 34 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-20 Completed Date: 2005-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: England |
Other Details:
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Languages: eng Pagination: 825-30 Citation Subset: IM |
Affiliation:
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Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anthropometry Blood Pressure / physiology* Cardiovascular Diseases / etiology Cholesterol, LDL / blood Cross-Sectional Studies Elasticity Humans Male Pulsatile Flow / physiology* Reference Values Risk Factors Smoking / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL |
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