| Determinants of atrial fibrillation development in patients with hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 15464672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Predictors of the development of atrial fibrillation (AF) in patients who have hypertrophic cardiomyopathy (HC) have not been extensively studied, although, in these patients, AF contributes to the exacerbation of symptoms and the development of heart failure. The present study determined the role of left atrial (LA) function in the development of AF in patients who have HC. One hundred fifty consecutive patients who had HC, had no history of AF, and who were followed for 5.2 +/- 2.9 years constituted the study population. Using M-mode echocardiography, we measured LA function as global LA fractional shortening and LA diameter. LA volume was measured from 2-dimensional 4-chamber views by the method of disks. During follow-up, 20 patients developed AF. LA function was an independent predictor of AF (odds ratio 0.716, p = <0.001), whereas LA diameter and volume were predictors in addition to age. Kaplan-Meier analysis showed that LA dysfunction carried a high risk of AF. Thus, in patients who have HC, LA function is a strong predictor of AF development and is independent of age. |
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Authors:
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Maria-Angela Losi; Sandro Betocchi; Mariano Aversa; Raffaella Lombardi; Marianna Miranda; Gianluigi D'Alessandro; Alessandra Cacace; Carlo-Gabriele Tocchetti; Giovanni Barbati; Massimo Chiariello |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 94 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-06 Completed Date: 2004-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 895-900 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Atrial Fibrillation / epidemiology, physiopathology* Atrial Function, Left / physiology Cardiomyopathy, Hypertrophic / epidemiology, physiopathology* Child Child, Preschool Echocardiography Female Follow-Up Studies Heart Atria / physiopathology, ultrasonography Humans Incidence Italy / epidemiology Male Middle Aged Multivariate Analysis Predictive Value of Tests |
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