| Determinants of adiponectin levels in patients with chronic systolic heart failure. | |
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MedLine Citation:
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PMID: 20381668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adiponectin, an adipocytokine, is secreted by adipocytes and mediates antihypertrophic and anti-inflammatory effects in the heart. Plasma concentrations of adiponectin are decreased in the presence of obesity, insulin resistance, and obesity-associated conditions such as hypertension and coronary heart disease. However, a paradoxical increase in adiponectin levels is observed in human systolic heart failure (HF). We sought to investigate the determinants of adiponectin levels in patients with chronic systolic HF. Total adiponectin levels were measured in 99 patients with stable HF and a left ventricular (LV) ejection fraction of <40%. The determinants of adiponectin levels on univariate analysis were included in a multivariate linear regression model. At baseline, 62% of the patients were black, 63% were men, the mean age was 60 + or - 13 years, the LV ejection fraction was 21 + or - 9%, and the body mass index was 30.6 + or - 6.7 kg/m(2). The mean adiponectin level was 15.8 + or - 15 microg/ml. Beta-Blocker use, body mass index, and blood urea nitrogen were significant determinants of adiponectin level on multivariate analysis. The LV mass, structure, and LV ejection fraction were not related to adiponectin levels on multivariate analysis. The effect of beta-blocker therapy was most marked in nonobese patients with a body mass index <30 kg/m(2). In conclusion, in patients with chronic systolic HF, beta-blocker therapy correlated with lower adiponectin levels, especially in nonobese patients. This relation should be taken into account when studying the complex role of adiponectin in patients with chronic systolic HF. |
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Authors:
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Andreia Biolo; Rei Shibata; Noriyuki Ouchi; Shinji Kihara; Mina Sonoda; Kenneth Walsh; Flora Sam |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-02-20 |
Journal Detail:
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Title: The American journal of cardiology Volume: 105 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-06-15 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1147-52 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Cardiology, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adrenergic beta-Antagonists / therapeutic use Biological Markers / blood* Disease Progression Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Heart Failure, Systolic / blood*, drug therapy, physiopathology Humans Male Middle Aged Outpatients Prognosis Retrospective Studies Severity of Illness Index Stroke Volume Ventricular Function, Left / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-04423/HL/NHLBI NIH HHS; HL-079099/HL/NHLBI NIH HHS; K23 HL004423-05/HL/NHLBI NIH HHS; R01 HL079099-04/HL/NHLBI NIH HHS; R21 HL095891-02/HL/NHLBI NIH HHS; R37 AG015052-15/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Adrenergic beta-Antagonists; 0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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