Document Detail

Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period.
MedLine Citation:
PMID:  11889014     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Elastic artery stiffness, a result of arterial aging, is an independent indicator of cardiovascular risk. The aim of the present longitudinal study was to compare the progression of aortic stiffness over a 6-year period in treated hypertensive subjects and normotensive subjects, and to evaluate the determinants of this progression. METHODS AND RESULTS: Data for the present analysis were gathered from 483 subjects who had 2 health checkups at the Centre d'Investigations Préventives et Cliniques, the first one in 1992--1993 and the second one in 1998--1999. Carotid-femoral pulse wave velocity (PWV) was used to evaluate aortic stiffness in 187 hypertensive subjects who were under treatment at the time of the first visit and throughout the follow-up period, and in 296 subjects who were classified as normotensive during the first visit and who remained treatment-free throughout the follow-up period. In both populations, PWV progression was higher in older subjects. Annual rates of progression in PWV in treated hypertensives were significantly higher than in normotensives. Only treated hypertensives with well-controlled blood pressure levels at the time of both visits had a PWV progression similar to that of normotensives. In treated hypertensives, high heart rate and high creatinine during the first visit were associated with an accelerated progression in PWV. CONCLUSIONS: The presence of high blood pressure, high heart rate, and high serum creatinine were the major determinants of accelerated progression of aortic stiffness in treated hypertensives. This is the first longitudinal study to evaluate the determinants of arterial aging over an extended period of time.
Athanase Benetos; Chris Adamopoulos; Jeanne-Marie Bureau; Mohamed Temmar; Carlos Labat; Kathryn Bean; Frédérique Thomas; Bruno Pannier; Roland Asmar; Mahmoud Zureik; Michel Safar; Louis Guize
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  105     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-12     Completed Date:  2002-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1202-7     Citation Subset:  AIM; IM    
Centre d'Investigations Préventives et Cliniques, Paris, France.
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MeSH Terms
Aging / blood
Analysis of Variance
Antihypertensive Agents / therapeutic use
Aorta / physiopathology*
Blood Pressure
Body Mass Index
Carotid Arteries / physiopathology
Cholesterol, HDL / blood
Creatinine / blood
Disease Progression
Femoral Artery / physiopathology
Follow-Up Studies
France / epidemiology
Heart Rate
Hypertension / drug therapy,  epidemiology,  physiopathology*
Longitudinal Studies
Middle Aged
Predictive Value of Tests
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Antihypertensive Agents; 0/Cholesterol, HDL; 0/Triglycerides; 60-27-5/Creatinine

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