Document Detail

Determinants of absolute and relative exercise-induced changes in B-type natriuretic peptides.
MedLine Citation:
PMID:  19897258     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Exercise is associated with changes in circulating B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP). However, the biological relevance of this phenomenon is poorly examined. We sought to assess determinants of absolute (Δ) and relative (Δ%) exercise-induced changes in BNP and NT-proBNP.
METHODS: BNP (n=418) and NT-proBNP (n=478) at rest and peak exercise were measured in patients undergoing symptom-limited cycle ergometer tests. Multivariate logistic regression was performed to identify predictors of high ΔBNP/ΔNT-proBNP and high ΔBNP/Δ%NT-proBNP defined as their highest quartiles (Q4).
RESULTS: The median (interquartile range) ΔBNP and ΔNT-proBNP was 12 (0-28) pg/ml and 7 (2-21) pg/ml respectively, and Δ%BNP and Δ%NT-proBNP was 21 (0-46) % and 7 (3-12) % respectively. Higher BNP [odds ratio (OR) 3.92 per ln unit; p<0.001] or NT-proBNP [OR 4.88 per ln unit; p<0.001] at rest was the strongest predictor of ΔBNP in Q4 (≥28pg/ml) or ΔNT-proBNP in Q4 (≥21pg/ml). In contrast, higher maximal work rate expressed as the percentage of the predicted value (OR 1.015 per %; p=0.007) was the only independent predictor of Δ%BNP in Q4 (≥46%), and lower resting heart rate (OR 0.97 per bpm; p=0.001) and lower age (OR 0.95 per year; p=0.001) were the only independent predictors of Δ%NT-proBNP in Q4 (≥12%).
CONCLUSIONS: Higher ΔBNP and ΔNT-proBNP primarily reflected higher BNP and NT-proBNP plasma levels at rest. In contrast, higher Δ%BNP and Δ%NT-proBNP were associated with several prognostically favorable features, indicating that higher Δ%BNP and Δ%NT-proBNP may be markers of health rather than disease.
Micha T Maeder; Daniel Staub; Yves Surnier; Tobias Reichlin; Markus Noveanu; Tobias Breidthardt; Mihael Potocki; Nora Schaub; David Conen; Christian Mueller
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Publication Detail:
Type:  Journal Article     Date:  2009-11-07
Journal Detail:
Title:  International journal of cardiology     Volume:  147     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  409-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Baker IDI Heart and Diabetes Institute and Heart Center, Alfred Hospital, Melbourne, Australia.
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