| Determinants of absolute and relative exercise-induced changes in B-type natriuretic peptides. | |
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MedLine Citation:
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PMID: 19897258 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Exercise is associated with changes in circulating B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP). However, the biological relevance of this phenomenon is poorly examined. We sought to assess determinants of absolute (Δ) and relative (Δ%) exercise-induced changes in BNP and NT-proBNP. METHODS: BNP (n=418) and NT-proBNP (n=478) at rest and peak exercise were measured in patients undergoing symptom-limited cycle ergometer tests. Multivariate logistic regression was performed to identify predictors of high ΔBNP/ΔNT-proBNP and high ΔBNP/Δ%NT-proBNP defined as their highest quartiles (Q4). RESULTS: The median (interquartile range) ΔBNP and ΔNT-proBNP was 12 (0-28) pg/ml and 7 (2-21) pg/ml respectively, and Δ%BNP and Δ%NT-proBNP was 21 (0-46) % and 7 (3-12) % respectively. Higher BNP [odds ratio (OR) 3.92 per ln unit; p<0.001] or NT-proBNP [OR 4.88 per ln unit; p<0.001] at rest was the strongest predictor of ΔBNP in Q4 (≥28pg/ml) or ΔNT-proBNP in Q4 (≥21pg/ml). In contrast, higher maximal work rate expressed as the percentage of the predicted value (OR 1.015 per %; p=0.007) was the only independent predictor of Δ%BNP in Q4 (≥46%), and lower resting heart rate (OR 0.97 per bpm; p=0.001) and lower age (OR 0.95 per year; p=0.001) were the only independent predictors of Δ%NT-proBNP in Q4 (≥12%). CONCLUSIONS: Higher ΔBNP and ΔNT-proBNP primarily reflected higher BNP and NT-proBNP plasma levels at rest. In contrast, higher Δ%BNP and Δ%NT-proBNP were associated with several prognostically favorable features, indicating that higher Δ%BNP and Δ%NT-proBNP may be markers of health rather than disease. |
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Authors:
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Micha T Maeder; Daniel Staub; Yves Surnier; Tobias Reichlin; Markus Noveanu; Tobias Breidthardt; Mihael Potocki; Nora Schaub; David Conen; Christian Mueller |
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Publication Detail:
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Type: Journal Article Date: 2009-11-07 |
Journal Detail:
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Title: International journal of cardiology Volume: 147 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 409-15 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Baker IDI Heart and Diabetes Institute and Heart Center, Alfred Hospital, Melbourne, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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