Document Detail


Determinants of abnormal maximum oxygen uptake after lung transplantation for chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  9883764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Single lung transplantation for chronic obstructive pulmonary disease relieves a ventilatory limit to incremental exercise, but maximum oxygen uptake remains abnormal. The purpose of this study was to define the relative contributions of Fick principle variables to abnormal aerobic capacity after lung transplantation. METHODS: Twelve paired incremental cardiopulmonary exercise test results obtained before and 3 to 6 months after single lung transplantation for chronic obstructive pulmonary disease were compared. RESULTS: Maximum workload nearly doubled after operation (42.5+/-4.2 vs 25.5+/-4.7 watts, P < .05). Peak exercise minute ventilation increased (32.8+/-3.3 vs 21+/-2.4 L/min, n = 11, P < .05), but maximum oxygen uptake remained markedly abnormal after transplantation (46.6%+/-4.4% vs 32.1%+/-2.9% predicted, P < .05, n = 8). Peak exercise cardiac output was normal (11.0+/-1.4 L/min, 89% predicted), but arterial-mixed venous oxygen content difference at peak exercise was only half of normal (7.2+/-0.61 mL/dL), as a result in part of the failure of mixed venous oxygen saturation to fall normally (peak exercise SvO2 = 49.8%+/-2.8%). CONCLUSIONS: Lung transplantation for chronic obstructive pulmonary disease relieves a ventilatory limit to exercise, but maximum aerobic capacity remains abnormal, in part because of abnormal systemic O2 extraction.
Authors:
D M Systrom; P Pappagianopoulos; R S Fishman; J C Wain; L C Ginns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  17     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-11     Completed Date:  1999-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1220-30     Citation Subset:  IM    
Affiliation:
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. systrom@helix.mgh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerobiosis
Cardiac Output
Exercise Test
Humans
Lung Diseases, Obstructive / physiopathology,  surgery*
Lung Transplantation*
Middle Aged
Oxygen / blood
Oxygen Consumption*
Pulmonary Gas Exchange
Pulmonary Ventilation*
Stroke Volume
Vital Capacity
Grant Support
ID/Acronym/Agency:
HL-07354/HL/NHLBI NIH HHS; KO8 HL2593-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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