| Determinants of abnormal maximum oxygen uptake after lung transplantation for chronic obstructive pulmonary disease. | |
| | |
MedLine Citation:
|
PMID: 9883764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Single lung transplantation for chronic obstructive pulmonary disease relieves a ventilatory limit to incremental exercise, but maximum oxygen uptake remains abnormal. The purpose of this study was to define the relative contributions of Fick principle variables to abnormal aerobic capacity after lung transplantation. METHODS: Twelve paired incremental cardiopulmonary exercise test results obtained before and 3 to 6 months after single lung transplantation for chronic obstructive pulmonary disease were compared. RESULTS: Maximum workload nearly doubled after operation (42.5+/-4.2 vs 25.5+/-4.7 watts, P < .05). Peak exercise minute ventilation increased (32.8+/-3.3 vs 21+/-2.4 L/min, n = 11, P < .05), but maximum oxygen uptake remained markedly abnormal after transplantation (46.6%+/-4.4% vs 32.1%+/-2.9% predicted, P < .05, n = 8). Peak exercise cardiac output was normal (11.0+/-1.4 L/min, 89% predicted), but arterial-mixed venous oxygen content difference at peak exercise was only half of normal (7.2+/-0.61 mL/dL), as a result in part of the failure of mixed venous oxygen saturation to fall normally (peak exercise SvO2 = 49.8%+/-2.8%). CONCLUSIONS: Lung transplantation for chronic obstructive pulmonary disease relieves a ventilatory limit to exercise, but maximum aerobic capacity remains abnormal, in part because of abnormal systemic O2 extraction. |
| | |
Authors:
|
D M Systrom; P Pappagianopoulos; R S Fishman; J C Wain; L C Ginns |
Related Documents
:
|
1735254 - Exercise testing in the evaluation of patients at high risk for complications from lung... 21419804 - Cognitive and locomotor/exploratory behavior after chronic exercise in the olfactory bu... 7615474 - Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema. 1110224 - Effect of preinspiratory lung volume on closing volume determination by nitrogen method. 23084704 - Exercise improves behavioral, neurocognitive, and scholastic performance in children wi... 10870864 - The effect of endurance training on parameters of aerobic fitness. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 17 ISSN: 1053-2498 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 1998 Dec |
Date Detail:
|
Created Date: 1999-03-11 Completed Date: 1999-03-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1220-30 Citation Subset: IM |
Affiliation:
|
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. systrom@helix.mgh.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aerobiosis Cardiac Output Exercise Test Humans Lung Diseases, Obstructive / physiopathology, surgery* Lung Transplantation* Middle Aged Oxygen / blood Oxygen Consumption* Pulmonary Gas Exchange Pulmonary Ventilation* Stroke Volume Vital Capacity |
| Grant Support | |
ID/Acronym/Agency:
|
HL-07354/HL/NHLBI NIH HHS; KO8 HL2593-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bezafibrate and lovastatin decrease the oxidizability of low-density lipoproteins in heart transplan...
Next Document: Metabolic myopathy as a cause of the exercise limitation in lung transplant recipients.