Document Detail


Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland.
MedLine Citation:
PMID:  19820427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued. METHODS: A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity. RESULTS: Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells >25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P<0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center. CONCLUSIONS: All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population.
Authors:
Catherine Myers; Klara M Posfay-Barbe; Christoph Aebi; Jean-Jacques Cheseaux; Christian Kind; Christoph Rudin; David Nadal; Claire-Anne Siegrist; ;
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  28     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-28     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  996-1001     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Geneva Medical School and University Hospitals of Geneva, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antibodies, Viral / blood
CD4 Lymphocyte Count
Child
Child, Preschool
Cohort Studies
Female
Guideline Adherence / statistics & numerical data*
HIV Infections / immunology*
Humans
Male
Prospective Studies
Switzerland
Vaccination / utilization*
Vaccines / immunology*
Viral Load
Young Adult
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Vaccines
Investigator
Investigator/Affiliation:
C Aebi / ; W B?r / ; Ch Berger / ; F Besson / ; U B?hlmann / ; J-J Cheseaux / ; D Desgrandchamps / ; A Diana / ; A Duppenthaler / ; A Gervaix / ; H P Gnehm / ; U Heininger / ; U A Hunzikerr / ; C Kahlert / ; C Kind / ; H Kuchler / ; A Loher / ; V Masserey-Spicher / ; C Myers / ; D Nadal / ; K Posfay-Barbe / ; C Rudin / ; U B Schaad / ; C-A Siegrist / ; J St?helin / ; B Vaudaux / ; C-A Wyler-Lazarevic / ; W Zingg / ; M Battegay / ; E Bernasconi / ; J B?ni / ; P Brazzola / ; H C Bucher / ; Ph B?rgisser / ; A Calmy / ; S Cattacin / ; M Cavassini / ; G Drack / ; R Dubs / ; M Egger / ; L Elzi / ; M Fischer / ; M Flepp / ; A Fontana / ; P Francioli / ; H J Furrer / ; C Fux / ; A Gayet-Ageron / ; S Gerber / ; M Gorgievski / ; H Gunthard / ; Th Gyr / ; H Hirsch / ; B Hirschel / ; I H?sli / ; M H?sler / ; L Kaiser / ; Ch Kahlert / ; U Karrer / ; Th Klimkait / ; B Ledergerber / ; G Martinetti / ; B Martinez / ; N M?ller / ; D Nadal / ; F Paccaud / ; G Pantaleo / ; L Raio / ; A Rauch / ; S Regenass / ; M Rickenbach / ; C Rudin / ; P Schmid / ; D Schultze / ; J Sch?pbach / ; R Speck / ; P Taff? / ; A Telenti / ; A Trkola / ; P Vernazza / ; R Weber / ; C-A Wyler / ; S Yerly /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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