| Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland. | |
| | |
MedLine Citation:
|
PMID: 19820427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued. METHODS: A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity. RESULTS: Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells >25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P<0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center. CONCLUSIONS: All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population. |
| | |
Authors:
|
Catherine Myers; Klara M Posfay-Barbe; Christoph Aebi; Jean-Jacques Cheseaux; Christian Kind; Christoph Rudin; David Nadal; Claire-Anne Siegrist; ; |
Related Documents
:
|
12026317 - Vaccine verification guide: demystifying childhood immunizations for inpatient and othe... 8822287 - Knowledge of the childhood immunization schedule and of contraindications to vaccinate ... 19845427 - Delivering vaccines: a case study of the distribution system of vaccines for children. 12690067 - The first oral rotavirus vaccine, 1998-1999: estimates of uptake from the national immu... 19059447 - Surveying a nationally representative internet-based panel to obtain timely estimates o... 21669247 - Impact of infant and preschool pertussis vaccinations on memory b-cell responses in chi... |
Publication Detail:
|
Type: Journal Article; Multicenter Study |
Journal Detail:
|
Title: The Pediatric infectious disease journal Volume: 28 ISSN: 1532-0987 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-28 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: United States |
Other Details:
|
Languages: eng Pagination: 996-1001 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Geneva Medical School and University Hospitals of Geneva, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Antibodies, Viral / blood CD4 Lymphocyte Count Child Child, Preschool Cohort Studies Female Guideline Adherence / statistics & numerical data* HIV Infections / immunology* Humans Male Prospective Studies Switzerland Vaccination / utilization* Vaccines / immunology* Viral Load Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Viral; 0/Vaccines |
| Investigator | |
Investigator/Affiliation:
|
C Aebi / ; W B?r / ; Ch Berger / ; F Besson / ; U B?hlmann / ; J-J Cheseaux / ; D Desgrandchamps / ; A Diana / ; A Duppenthaler / ; A Gervaix / ; H P Gnehm / ; U Heininger / ; U A Hunzikerr / ; C Kahlert / ; C Kind / ; H Kuchler / ; A Loher / ; V Masserey-Spicher / ; C Myers / ; D Nadal / ; K Posfay-Barbe / ; C Rudin / ; U B Schaad / ; C-A Siegrist / ; J St?helin / ; B Vaudaux / ; C-A Wyler-Lazarevic / ; W Zingg / ; M Battegay / ; E Bernasconi / ; J B?ni / ; P Brazzola / ; H C Bucher / ; Ph B?rgisser / ; A Calmy / ; S Cattacin / ; M Cavassini / ; G Drack / ; R Dubs / ; M Egger / ; L Elzi / ; M Fischer / ; M Flepp / ; A Fontana / ; P Francioli / ; H J Furrer / ; C Fux / ; A Gayet-Ageron / ; S Gerber / ; M Gorgievski / ; H Gunthard / ; Th Gyr / ; H Hirsch / ; B Hirschel / ; I H?sli / ; M H?sler / ; L Kaiser / ; Ch Kahlert / ; U Karrer / ; Th Klimkait / ; B Ledergerber / ; G Martinetti / ; B Martinez / ; N M?ller / ; D Nadal / ; F Paccaud / ; G Pantaleo / ; L Raio / ; A Rauch / ; S Regenass / ; M Rickenbach / ; C Rudin / ; P Schmid / ; D Schultze / ; J Sch?pbach / ; R Speck / ; P Taff? / ; A Telenti / ; A Trkola / ; P Vernazza / ; R Weber / ; C-A Wyler / ; S Yerly / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TWIN PRETERM NEONATES WITH CARDIAC TOXICITY RELATED TO LOPINAVIR/RITONAVIR THERAPY.
Next Document: Candida skin testing is a poor adjunct to tuberculin skin testing in international adoptees.