| Determinants of severe hypoglycemia complicating type 2 diabetes: the Fremantle diabetes study. | |
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MedLine Citation:
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PMID: 20305006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: There are limited published data characterizing severe hypoglycemia complicating type 2 diabetes. OBJECTIVE: The objective of the study was to determine the incidence and predictors of severe hypoglycemia in community-dwelling type 2 patients. DESIGN: This was a longitudinal observational cohort study. SETTING: This was a community-based study. PATIENTS: There were 616 patients (mean age 67.0 yr, 52.3% males, median diabetes duration 7.7 yr) assessed in 1998 and followed up to the end of June 2006. MAIN OUTCOME MEASURES: Severe hypoglycemia defined as that requiring ambulance attendance, emergency department services, and/or hospitalization. Cox proportional hazards modeling was used to determine predictors of first episode, and Poisson, negative binomial, zero-inflated Poisson, and zero-inflated negative binomial regression models identified predictors of frequency. RESULTS: Fifty-two (8.4%) experienced 66 episodes during 3953 patient-years (incidence 1.7 per 100 patient-years). Those experiencing severe hypoglycemia had one to four episodes. Significant independent predictors of time to first episode were duration of insulin treatment, estimated glomerular filtration rate less than 60 ml/min per 1.73 m(2), peripheral neuropathy, education beyond primary level, and past severe hypoglycemia. The zero-inflated negative binomial provided the best model of severe hypoglycemia frequency. Lower fasting serum glucose and higher glycosylated hemoglobin were significantly associated with frequency, whereas patients at minimal risk of repeated severe hypoglycemia were unlikely to use insulin or to have short-duration insulin treatment, to have renal impairment or peripheral neuropathy, or to be educated beyond primary level. CONCLUSIONS: Duration of insulin treatment was confirmed as an independent risk factor for severe hypoglycemia. The novel association with educational attainment suggests knowledge-driven intensive glycemic self-management. The positive relationship between frequency and glycosylated hemoglobin may identify patients with unstable glycemic control. |
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Authors:
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Timothy M E Davis; Simon G A Brown; Ian G Jacobs; Max Bulsara; David G Bruce; Wendy A Davis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-19 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2240-7 Citation Subset: AIM; IM |
Affiliation:
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University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia. tdavis@cyllene.uwa.edu.au |
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| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 2
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complications* Educational Status Emergencies / epidemiology Female Glomerular Filtration Rate Hemoglobin A, Glycosylated / analysis Hospitalization / statistics & numerical data Humans Hypoglycemia / epidemiology*, etiology Hypoglycemic Agents / adverse effects, therapeutic use Incidence Insulin / adverse effects, therapeutic use Male Poisson Distribution Predictive Value of Tests Proportional Hazards Models Regression Analysis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 11061-68-0/Insulin |
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