| Determinants of Physiologic (18)F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations. | |
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MedLine Citation:
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PMID: 20852948 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to assess independent predictors of 2-deoxy-2-[(18)F]fluoro-D: -glucose ((18)F-FDG) uptake in brown adipose tissue (BAT) in patients undergoing repeated positron emission tomography (PET)/computed tomography (CT) scans. PROCEDURES: Eight hundred forty-eight (mean age 50.9 ± 16 years) patients in whom PET/CT scan was repeated (mean interval 5 ± 1.5 months) constituted the study group. (18)F-FDG uptake in characteristic areas of BAT, with CT density of adipose tissue, greater than background soft-tissue activity was considered as evidence of BAT uptake. Both distribution and maximum standardized uptake values (SUVmax) were registered. Clinical and anamnestic data were collected for each patient. RESULTS: (18)F-FDG uptake in BAT was present in 8.6% patients at first scan. Independent predictors of presence of uptake were age (younger), gender (female), body mass index (lower), and maximum outdoor temperature (lower). Age was the only independent predictor of BAT (18)F-FDG uptake distribution, while SUVmax was related to both age and outdoor temperature. Independent determinants of persistence of BAT (18)F-FDG uptake at second PET/CT were outdoor temperature at time of second scan and extension of metabolically active BAT at first scan. CONCLUSIONS: Age, body mass index, and outdoor temperature are significant determinants of BAT evidence at (18)F-FDG PET/CT. Moreover, extension of BAT and outdoor temperature are the strongest determinants of persistence of BAT evidence on (18)F-FDG PET/CT in repeated scan. |
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Authors:
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Leonardo Pace; Emanuele Nicolai; Domenico D'Amico; Francesco Ibello; Anna Maria Della Morte; Barbara Salvatore; Laura Micol Pizzuti; Marco Salvatore; Andrea Soricelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 13 ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1029-35 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Biomorfologiche e Funzionali, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Edificio 10, via Pansini 5, 80131, Napoli, Italy, pace@unina.it. |
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