Document Detail


Determinants of expiratory flow limitation in healthy women during exercise.
MedLine Citation:
PMID:  21364489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Expiratory flow limitation (EFL) can occur in healthy young women during exercise. We questioned whether the occurrence and severity of EFL were related to aerobic fitness or anatomical factors.
METHODS: Twenty-two healthy young (<40 yr) women performed a progressive cycle test to exhaustion. The subjects' maximum expiratory flow-volume curve was compiled from several effort-graded vital capacity maneuvers before and after exercise. The maximum expiratory flow-volume curve, along with inspiratory capacity maneuvers, was used to determine lung volumes and expiratory flows and to quantify EFL. To determine relative airway size, we used a ratio sensitive to both airway size and lung volume, called the dysanapsis ratio. The subjects were partitioned into two groups based upon the appearance of >5% EFL.
RESULTS: Ten subjects showed EFL during exercise. Forced vital capacities (4.4 ± 0.4 vs 3.7 ± 0.4 L, P < 0.001) and forced expiratory flows for any given lung volume were significantly larger in the non-expiratory flow-limited (NEFL) group. The NEFL group's dysanapsis ratio was significantly larger than that of the EFL group (0.27 ± 0.06 vs 0.21 ± 0.04, respectively, P < 0.05), indicating larger airways in the NEFL group. There was no difference between the NEFL and EFL groups with respect to maximal aerobic capacity (50.8 ± 10.0 vs 46.7 ± 5.9 mL·kg(-1)·min(-1), respectively, P = 0.264). At peak exercise, the NEFL group had a significantly higher end-expiratory lung volume than the EFL group (40.1% ± 4.8% vs 33.7% ± 5.7% FVC, respectively, P < 0.05).
CONCLUSIONS: We conclude that EFL in women can largely be explained by anatomical factors that influence the capacity to generate flow and volume during exercise rather than fitness per se.
Authors:
Paolo B Dominelli; Jordan A Guenette; Sabrina S Wilkie; Glen E Foster; A William Sheel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  43     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-11-23     Completed Date:  2012-03-28     Revised Date:  2012-06-29    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1666-74     Citation Subset:  IM; S    
Affiliation:
School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise / physiology*
Exhalation*
Female
Humans
Oxygen Consumption / physiology
Pulmonary Ventilation / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Comments/Corrections
Comment In:
Med Sci Sports Exerc. 2012 Jun;44(6):1194; author reply 1195   [PMID:  22592279 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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