| Determinants of Expiratory Flow Limitation in Healthy Women during Exercise. | |
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MedLine Citation:
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PMID: 21364489 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:: Expiratory flow limitation (EFL) can occur in healthy young women during exercise. We questioned whether the occurrence and severity of EFL was related to aerobic fitness or anatomical factors. METHODS:: Twenty-two healthy young (<40 yrs) women performed a progressive cycle test to exhaustion. Subject's maximum expiratory flow-volume (MEFV) curve was compiled from several effort-graded vital capacity maneuvers before and after exercise. The MEFV curve, along with inspiratory capacity maneuvers, was used to determine lung volumes, expiratory flows and to quantify EFL. To determine relative airway size, we used a ratio sensitive to both airway size and lung volume; referred to as the dysanapsis ratio. The subjects were partitioned into two groups based upon the appearance of > 5% EFL. RESULTS:: Ten subjects showed EFL during exercise. Forced vital capacities (4.4 ± 0.4 vs. 3.7 ± 0.4 l, P<0.001) and forced expiratory flows for any given lung volume were significantly larger in the nonexpiratory flow limited (NEFL) group. The NEFL group's dysanapsis ratio was significantly larger than the EFL group (0.27 ± 0.06 vs. 0.21 ± 0.04, P<0.05; respectively); indicating larger airways in the NEFL group. There was no difference between the NEFL and EFL group with respect to maximal aerobic capacity (50.8 ± 10.0 vs. 46.7 ± 5.9 ml·kg-1·min-1, P = 0.264; respectively). At peak exercise the NEFL group had a significantly higher end-expiratory lung volume than the EFL group (40.1 ± 4.8 vs. 33.7 ± 5.7 % FVC, P<0.05; respectively). CONCLUSION:: We conclude that EFL in women can largely be explained by anatomical factors that influence the capacity to generate flow and volume during exercise rather than fitness per se. |
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Authors:
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Paolo B Dominelli; Jordan A Guenette; Sabrina S Wilkie; Glen E Foster; A William Sheel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-28 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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