| Determinants of expiratory flow limitation in healthy women during exercise. | |
| | |
MedLine Citation:
|
PMID: 21364489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Expiratory flow limitation (EFL) can occur in healthy young women during exercise. We questioned whether the occurrence and severity of EFL were related to aerobic fitness or anatomical factors. METHODS: Twenty-two healthy young (<40 yr) women performed a progressive cycle test to exhaustion. The subjects' maximum expiratory flow-volume curve was compiled from several effort-graded vital capacity maneuvers before and after exercise. The maximum expiratory flow-volume curve, along with inspiratory capacity maneuvers, was used to determine lung volumes and expiratory flows and to quantify EFL. To determine relative airway size, we used a ratio sensitive to both airway size and lung volume, called the dysanapsis ratio. The subjects were partitioned into two groups based upon the appearance of >5% EFL. RESULTS: Ten subjects showed EFL during exercise. Forced vital capacities (4.4 ± 0.4 vs 3.7 ± 0.4 L, P < 0.001) and forced expiratory flows for any given lung volume were significantly larger in the non-expiratory flow-limited (NEFL) group. The NEFL group's dysanapsis ratio was significantly larger than that of the EFL group (0.27 ± 0.06 vs 0.21 ± 0.04, respectively, P < 0.05), indicating larger airways in the NEFL group. There was no difference between the NEFL and EFL groups with respect to maximal aerobic capacity (50.8 ± 10.0 vs 46.7 ± 5.9 mL·kg(-1)·min(-1), respectively, P = 0.264). At peak exercise, the NEFL group had a significantly higher end-expiratory lung volume than the EFL group (40.1% ± 4.8% vs 33.7% ± 5.7% FVC, respectively, P < 0.05). CONCLUSIONS: We conclude that EFL in women can largely be explained by anatomical factors that influence the capacity to generate flow and volume during exercise rather than fitness per se. |
| | |
Authors:
|
Paolo B Dominelli; Jordan A Guenette; Sabrina S Wilkie; Glen E Foster; A William Sheel |
Related Documents
:
|
3826409 - Effects of endurance training and captivity on activity metabolism of lizards. 10066139 - Higher mitochondrial fatty acid oxidation following intermittent versus continuous endu... 8976309 - Lower extremity blood flow and responses to occlusion ischemia differ in exercise-train... 10090329 - Serial effects of high-resistance and prolonged endurance training on na+-k+ pump conce... 9459529 - The effect of physical conditioning on antipyrine clearance. 22872989 - Physiological responses of astronaut candidates to simulated +gx orbital emergency re-e... 2793669 - Recovery of short-term power after dynamic exercise. 17148319 - Sex and the single (-eared) female: leg function, limb autotomy and mating history trad... 3122549 - Sustained antianginal efficacy of transdermal nitroglycerin patches using an overnight ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Medicine and science in sports and exercise Volume: 43 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-11-23 Completed Date: 2012-03-28 Revised Date: 2012-06-29 |
Medline Journal Info:
|
Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
|
Languages: eng Pagination: 1666-74 Citation Subset: IM; S |
Affiliation:
|
School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Exercise / physiology* Exhalation* Female Humans Oxygen Consumption / physiology Pulmonary Ventilation / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
//Canadian Institutes of Health Research |
| Comments/Corrections | |
Comment In:
|
Med Sci Sports Exerc. 2012 Jun;44(6):1194; author reply 1195
[PMID:
22592279
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of an Eight-Month Exercise Training Program on Off-Exercise Physical Activity.
Next Document: Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mecha...