Document Detail


Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.
MedLine Citation:
PMID:  22113088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N=324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.
Authors:
Frauke Nees; Jelka Tzschoppe; Christopher J Patrick; Sabine Vollstädt-Klein; Sabina Steiner; Luise Poustka; Tobias Banaschewski; Gareth J Barker; Christian Büchel; Patricia J Conrod; Hugh Garavan; Andreas Heinz; Jürgen Gallinat; Mark Lathrop; Karl Mann; Eric Artiges; Tomas Paus; Jean-Baptiste Poline; Trevor W Robbins; Marcella Rietschel; Michael N Smolka; Rainer Spanagel; Maren Struve; Eva Loth; Gunter Schumann; Herta Flor;
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-23
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  37     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-11-19     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  986-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Age of Onset
Alcoholism / diagnosis,  epidemiology,  psychology*
Cohort Studies
Early Diagnosis
Female
Humans
Impulsive Behavior / chemically induced,  epidemiology,  psychology*
Magnetic Resonance Imaging / methods*
Male
Personality / physiology*
Predictive Value of Tests
Reward*
Risk Factors
Risk-Taking*
Grant Support
ID/Acronym/Agency:
93558//Medical Research Council; G0901858//Medical Research Council
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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