| Determinants of ELISA D-dimer sensitivity for unstable angina pectoris as defined by coronary catheterization. | |
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MedLine Citation:
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PMID: 15164376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Unstable angina pectoris is associated with elevated D-dimer levels. However, the operating characteristics (sensitivity, specificity, positive and negative predictive value) of the D-dimer assay for the diagnosis of coronary artery disease (CAD) are unknown. Using a prospective, observational design, we collected blood from 54 patients with unstable angina pectoris at admission and assayed for ELISA D-dimer levels. The sensitivity, specificity, and negative and positive prediction values for angiographically determined coronary artery disease were calculated at multiple discriminate levels. All patients underwent coronary catheterization. A statistically significant correlation was noted between ELISA D-dimer levels and age, male sex, hypertension, use of beta-blocker, fibrinogen levels and catheterization findings. No correlation was noted between ELISA D-dimer levels and degree of the coronary artery disease. Best results were provided at a discriminate level of 270 ng/ml, with sensitivity 70%, negative predictive value 72%, and overall accuracy 67%. All discriminate levels, however, provided values too low for diagnosis. In conclusion, ELISA D-dimer assay is a non-sensitive, non-specific test for coronary artery disease as defined by coronary catheterization. However, the assay adds information regarding the severity of disease in patients presenting with acute coronary syndrome. |
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Authors:
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David Shitrit; Ariella Bar-Gil Shitrit; Bernard Rudensky; Jaqueline Sulkes; Dan Tzviony |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 76 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-27 Completed Date: 2004-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 121-5 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel. davariel@zahav.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina, Unstable
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blood,
chemically induced*,
radiography Biological Markers / blood Coronary Disease / blood, diagnosis Enzyme-Linked Immunosorbent Assay / methods Female Fibrin Fibrinogen Degradation Products / analysis* Heart Catheterization* Humans Male Middle Aged Observer Variation Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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