Document Detail

Deterioration of exercise capacity after neonatal extracorporeal membrane oxygenation.
MedLine Citation:
PMID:  21540306     Owner:  NLM     Status:  MEDLINE    
Extracorporeal membrane oxygenation (ECMO) provides life support in acute reversible cardiorespiratory failure. Assessment of long-term morbidity is essential to confirm survival advantage. This study aimed to assess exercise capacity in the first 12 yrs of life after neonatal ECMO, and to evaluate the effect of primary diagnosis, lung function or perinatal characteristics on exercise capacity. 120 children who, as neonates, underwent ECMO performed 191 reliable exercise tests according to the Bruce treadmill protocol at ages 5, 8 and/or 12 yrs between 2001 and 2010. Primary diagnoses were meconium aspiration syndrome (n=66), congenital diaphragmatic hernia (n=18) and other diagnoses (n=36). At ages 5, 8 and 12 yrs, ANOVA resulted in mean ± se standard deviation score endurance time on the treadmill of -0.5 ± 0.1, -1.1 ± 0.1, and -1.5 ± 0.2, respectively, all significantly less than zero (p<0.001). Exercise capacity declined significantly over time irrespective of the primary diagnosis. Neonates treated with ECMO are at risk of decreased exercise capacity at school age. We therefore propose prolonged follow-up. Proactive advice on sports participation or referral to a physical therapist is recommended, especially when either the parents or the children themselves report impaired exercise capacity.
M H M van der Cammen-van Zijp; S J Gischler; W C J Hop; J C de Jongste; D Tibboel; H Ijsselstijn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-03
Journal Detail:
Title:  The European respiratory journal     Volume:  38     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-02     Completed Date:  2012-06-20     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1098-104     Citation Subset:  IM    
Depts of Intensive Care, Erasmus MC–Sophia Children's Hospital, Rotterdam, The Netherlands.
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MeSH Terms
Blood Gas Monitoring, Transcutaneous
Child, Preschool
Exercise Test
Exercise Tolerance*
Extracorporeal Membrane Oxygenation / adverse effects*
Follow-Up Studies
Forced Expiratory Volume
Infant, Newborn
Vital Capacity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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