| Deterioration of cortical responses to amplitude modulations of low-frequency carriers after high-frequency cochlear lesion in guinea pigs. | |
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MedLine Citation:
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PMID: 20151931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Temporal modulation transfer function (TMTF) is one of the most common methods for evaluating temporal acuity in the auditory system. In this experiment, we recorded cortical responses to amplitude modulation of tone carriers from implanted electrodes in guinea pigs to generate TMTFs by calculating the response amplitude changes as a function of modulation frequencies (Mfs). High-frequency hearing loss above 8 kHz was established using tone overstimulation (12 kHz, 110 dB SPL for 30 hours). The impact of this acoustic trauma on temporal resolution in the low-frequency range (below and at 8 kHz) was evaluated with the repeated tests of TMTFs until eight weeks post trauma. Deterioration in temporal resolution was found to develop over time, especially at 2 kHz, which was indicated by the decrease in -3 dB cutoffs in TMTFs and by the overall decrease in the AM response amplitude. Potential mechanisms that may underlie this off-channel affect are discussed. |
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Authors:
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Yanmei Feng; Shankai Yin; Jian Wang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of audiology Volume: 49 ISSN: 1708-8186 ISO Abbreviation: Int J Audiol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140017 Medline TA: Int J Audiol Country: England |
Other Details:
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Languages: eng Pagination: 228-37 Citation Subset: IM |
Affiliation:
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The Affiliated Sixth People's Hospital, Otorhinolaryngology Institute, Shanghai Jiao Tong University, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Auditory Cortex / physiopathology* Cochlea / injuries Evoked Potentials, Auditory* Guinea Pigs Hearing Loss, High-Frequency / physiopathology* Hearing Loss, Noise-Induced / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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