Document Detail

Detection of weak graft-versus-host reactions by the suppressive effect on the immune response (author's transl)
MedLine Citation:
PMID:  23066     Owner:  NLM     Status:  MEDLINE    
Weak graft-versus-host reactions induced between H-2 compatible strains are not detected by the splenomegaly assay in newborn mice. Similarly the proliferative response in the mixed lymphocyte culture or the popliteal lymph node assay was not extensive in some combinations. On the contrary, the inhibition of the specific immune response to heterologous red cells was observed when graft occurred from 15 days before immunization. So the weak graft-versus-host reactions appeared to be easily detected by the suppressive effect on antibody synthesis.
G Marchal
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Annales d'immunologie     Volume:  128     ISSN:  0300-4910     ISO Abbreviation:  Ann. Immunol. (Paris)     Publication Date:    1977 Nov-Dec
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0353045     Medline TA:  Ann Immunol (Paris)     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  1085-9     Citation Subset:  IM    
Vernacular Title:
Détection des réactions du greffon contre l'hôte de faible intensité par l'inhibition de la résponse immunitaire spécifique.
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MeSH Terms
Animals, Newborn / immunology
Antibody Formation*
Graft vs Host Reaction*
H-2 Antigens
Mice, Inbred BALB C
Mice, Inbred DBA
Radiation Chimera
Reg. No./Substance:
0/H-2 Antigens

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