| Detection of von Willebrand factor and tissue factor in platelets-fibrin rich coronary thrombi in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 16377278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rapid closure of coronary arteries due to occlusive thrombi is the major cause of acute myocardial infarction. However, the mechanisms of coronary thrombus formation have not been elucidated. We immunohistochemically assessed the localizations and their changes over time of glycoprotein IIb/IIIa, fibrin, von Willebrand factor (vWF), and tissue factor (TF), after the onset of chest pain (<4, 4 to 6, or 6 to 12 hours), in fresh coronary thrombi causing acute myocardial infarction. The occlusive thrombi were consistently composed of platelets, fibrin, vWF, and TF from the early phase of onset, and glycoprotein IIb/IIIa and fibrin were closely associated with vWF and TF, respectively. vWF and/or TF may contribute to occlusive thrombus formation and be novel therapeutic candidates for treating patients with coronary thrombosis. |
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Authors:
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Atsushi Yamashita; Takahiro Sumi; Shinya Goto; Yasunari Hoshiba; Kensaku Nishihira; Riichirou Kawamoto; Kinta Hatakeyama; Haruhiko Date; Takuroh Imamura; Hisao Ogawa; Yujiro Asada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-11-07 |
Journal Detail:
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Title: The American journal of cardiology Volume: 97 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-26 Completed Date: 2006-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 26-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, University of Miyazaki Faculty of Medicine, Miyazaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Platelets / metabolism* Coronary Thrombosis / metabolism*, pathology Female Fibrin / metabolism* Humans Immunohistochemistry Male Middle Aged Myocardial Infarction / metabolism, pathology Platelet Glycoprotein GPIIb-IIIa Complex / metabolism Thromboplastin / metabolism* von Willebrand Factor / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Platelet Glycoprotein GPIIb-IIIa Complex; 0/von Willebrand Factor; 9001-31-4/Fibrin; 9035-58-9/Thromboplastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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