| Detection of viral deoxyribonucleic acid in amniotic fluid: association with fetal malformation and pregnancy abnormalities. | |
| | |
MedLine Citation:
|
PMID: 15824499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To first test the hypothesis that the presence of viral nucleic acid in amniotic fluid (AF) is associated with an abnormal pregnancy outcome, and second, to determine if the overall rate of polymerase chain reaction (PCR) positivity and the distribution of virus types vary geographically. STUDY DESIGN: Cytomegalovirus (CMV), parvovirus B19, adenovirus, enterovirus, herpes simplex virus, Epstein-Barr virus, and respiratory syncytial virus nucleic acids were sought in 423 AF samples obtained for clinical indications: 284 from the East Coast (EC) and 139 from the Midwest (MW). RESULTS: Gestational age at sampling was 19.1 weeks for EC and 20.1 weeks for MW. 13.5% of karyotypically normal singleton pregnancies (57/423) had a positive AF PCR. 11% of AF PCR from the EC while 18% of AF PCR from the MW were positive (p = 0.06). The most commonly detected viruses were adenovirus (77%), enterovirus (12%), and CMV and parvovirus B19 (5% each). Twenty-four percent of sonographically abnormal pregnancies (33/136) had a positive AF PCR compared to only 8.4% (24/287) of normal pregnancies (p < 0.001). CONCLUSION: A positive AF PCR is associated with an increased rate of fetal structural malformations, intrauterine growth restriction, hydrops and other fetal abnormalities. There were no significant geographic differences in the incidence of AF viral PCR positivity. |
| | |
Authors:
|
Uma M Reddy; Ahmet A Baschat; Marya G Zlatnik; Jeffrey A Towbin; Christopher R Harman; Carl P Weiner |
Related Documents
:
|
18043469 - Biological matrices for the evaluation of in utero exposure to drugs of abuse. 8677069 - Normal values for amniotic fluid index during uncomplicated twin pregnancy. 9457979 - Fetal fibronectin concentration in amniotic fluid decreases with advancing gestational ... 3369499 - Permeability of placenta to inulin. 11725739 - Successful enucleation of a necrotizing fibroid causing oligohydramnios and fetal postu... 14634579 - Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influe... 6879369 - Prazosin and oxprenolol therapy in pregnancy hypertension. 19743889 - Effect of cytochrome p450 2d6 genotype on maternal paroxetine plasma concentrations dur... 1415949 - Intestinal obstruction complicating pregnancy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Fetal diagnosis and therapy Volume: 20 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2005 May-Jun |
Date Detail:
|
Created Date: 2005-04-12 Completed Date: 2005-07-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 203-7 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2005 S. Karger AG, Basel. |
Affiliation:
|
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201-1703, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amniocentesis Amniotic Fluid / chemistry* Cross-Sectional Studies DNA, Viral / analysis* Demography Edema / epidemiology Female Fetal Growth Retardation / epidemiology Fetus / abnormalities* Gestational Age Humans Karyotyping Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious / epidemiology*, virology Prevalence Ultrasonography, Prenatal United States Virus Diseases / epidemiology Viruses / isolation & purification |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antenatal presentation of isolated femoral hypoplasia discovered at 18 weeks of gestation.
Next Document: Epidural local anesthetics: a novel treatment for fetal growth retardation?