Document Detail


Detection of a vasoconstrictor factor in stroma-free haemoglobin solutions.
MedLine Citation:
PMID:  3418756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymerised pyridoxylated haemoglobin solution (PPSFH) is a modified haemoglobin solution which has a normal oxygen carrying capacity, long half-life, and reasonable oxygen affinity, and is a leading candidate for use as an oxygen carrying blood substitute. Previous work has given indications that vasoactive factors may be present. A bioassay sensitive to vasoconstrictors was constructed. PPSFH prepared by chloroform extraction produced a mean pressure rise of 24.3 mm Hg. PPSFH prepared by a crystallisation method showed a mean rise of 2 mm Hg (p = 0.0004). Unmodified stroma-free haemoglobin (SFH) prepared from platelet- and white cell-free red blood cells showed a mean rise of 32.5 mm Hg. These data indicate that both PPSFH and SFH contain a vasoconstrictor factor which is of low molecular weight, is hydrophilic, and is derived from red blood cells.
Authors:
D Gilroy; C Shaw; E Parry; W Odling-Smee
Related Documents :
8898456 - Hyperbaric oxygen chambers and the treatment of sports injuries.
9278706 - Sodium cyanate: from a promising therapeutic agent to a research tool in high altitude ...
6430006 - Transcutaneous oxygen measurement during one-lung anaesthesia.
16205326 - Evidence for myocardial defects under extreme acute normovolemic hemodilution with hydr...
20828746 - Continuous-flow cardiac assistance: effects on aortic valve function in a mock loop.
10875036 - Normalization of left ventricular dysfunction in systemic hypertension.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of trauma     Volume:  28     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-17     Completed Date:  1988-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1312-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Queen's University of Belfast, Northern Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / drug effects
Biological Assay
Hemoglobins / analysis*,  pharmacology
Norepinephrine / pharmacology
Pressure
Rabbits
Vasoconstriction / drug effects
Vasoconstrictor Agents / analysis*
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Vasoconstrictor Agents; 0/hemoglobin, stroma free; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacological reversal of abnormal glucose regulation, BCAA utilization, and muscle catabolism in ...
Next Document:  Major bowel and diaphragmatic injuries associated with blunt spleen or liver rupture.