Document Detail

Detection of a vasoconstrictor factor in stroma-free haemoglobin solutions.
MedLine Citation:
PMID:  3418756     Owner:  NLM     Status:  MEDLINE    
Polymerised pyridoxylated haemoglobin solution (PPSFH) is a modified haemoglobin solution which has a normal oxygen carrying capacity, long half-life, and reasonable oxygen affinity, and is a leading candidate for use as an oxygen carrying blood substitute. Previous work has given indications that vasoactive factors may be present. A bioassay sensitive to vasoconstrictors was constructed. PPSFH prepared by chloroform extraction produced a mean pressure rise of 24.3 mm Hg. PPSFH prepared by a crystallisation method showed a mean rise of 2 mm Hg (p = 0.0004). Unmodified stroma-free haemoglobin (SFH) prepared from platelet- and white cell-free red blood cells showed a mean rise of 32.5 mm Hg. These data indicate that both PPSFH and SFH contain a vasoconstrictor factor which is of low molecular weight, is hydrophilic, and is derived from red blood cells.
D Gilroy; C Shaw; E Parry; W Odling-Smee
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of trauma     Volume:  28     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-17     Completed Date:  1988-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1312-6     Citation Subset:  AIM; IM    
Department of Surgery, Queen's University of Belfast, Northern Ireland.
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MeSH Terms
Arteries / drug effects
Biological Assay
Hemoglobins / analysis*,  pharmacology
Norepinephrine / pharmacology
Vasoconstriction / drug effects
Vasoconstrictor Agents / analysis*
Reg. No./Substance:
0/Hemoglobins; 0/Vasoconstrictor Agents; 0/hemoglobin, stroma free; 51-41-2/Norepinephrine

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