| Detection of upper airway muscle involvement in neuromuscular disorders using the flow-volume loop. | |
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MedLine Citation:
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PMID: 3720386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormal contours of the flow-volume loop, ie, flow oscillations and inspiratory flow plateaux, have been noted in disorders affecting upper-airway muscular function. In this study, we assessed the incidence and the value of these contours as a test of bulbar and upper-airway muscular involvement in neuromuscular disease. We therefore compared flow-volume loops and pulmonary function test results between ten patients with (group 1) and 20 patients without (group 2) clinically apparent bulbar muscle involvement in neuromuscular disease. An abnormal flow-volume loop occurred significantly more often in group 1 than in group 2 (9/10 or 90 percent vs 3/20 or 15 percent, respectively; p less than 0.001) and predicted bulbar and upper-airway muscle involvement with high sensitivity (90 percent), specificity (85 percent) and efficiency (87 percent). Based on commonly used spirometric criteria, upper-airway obstruction was not more common in group 1 than in group 2 (1/10 vs 2/20); however, all three patients with upper-airway obstruction suggested by these criteria had an abnormal flow-volume loop. Following this study, three patients incurred severe respiratory complications. All three patients had previously shown an abnormal flow-volume loop. We conclude that in patients with neuromuscular disease, involvement of the bulbar and upper-airway muscles is frequently associated with an abnormal contour of the flow-volume loop. Recognition of flow oscillations or flow plateaux on flow-volume loops in these patients seems important, since they may be potential markers of severe respiratory complications. |
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Authors:
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W Vincken; G Elleker; M G Cosio |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Chest Volume: 90 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-08-04 Completed Date: 1986-08-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 52-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Forced Expiratory Volume Humans Lung Diseases, Obstructive / diagnosis*, etiology, physiopathology Lung Volume Measurements Male Middle Aged Neurologic Examination Neuromuscular Diseases / complications, diagnosis*, physiopathology Pulmonary Ventilation* Respiratory Function Tests Vital Capacity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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