| Detection of unsuspected distant metastases and/or regional nodes by FDG-PET [corrected] scan in apparent limited-disease small-cell lung cancer. | |
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MedLine Citation:
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PMID: 17537538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We retrospectively investigated the clinical usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) for evaluation of patients with limited-disease small-cell lung cancer (LD-SCLC) diagnosed by conventional staging procedures. Sixty-three patients received whole body FDG-PET scans after routine initial staging procedures. The findings of FDG-PET scans suggesting extensive-stage disease were confirmed by other imaging tests or by the patient's clinical course. FDG-PET scan findings indicated distant metastases in 6 of 63 patients. Metastatic disease was confirmed in five of these six patients (8%, 95% confidence interval: 3-18%). FDG-PET scan also detected regional lymph node metastases even in nine patients (14%) in whom computed tomography images had been negative, including contralateral lymph node metastasis in three patients. FDG-PET scan detected additional lesions in patients diagnosed as having LD-SCLC by conventional staging procedures. The therapeutic strategies were changed in 8% of patients based on the results of FDG-PET. FDG-PET scan is recommended as an initial staging tool for patients with this disease. |
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Authors:
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Seiji Niho; Hirofumi Fujii; Koji Murakami; Seisuke Nagase; Kiyotaka Yoh; Koichi Goto; Hironobu Ohmatsu; Kaoru Kubota; Ryuzo Sekiguchi; Shigeru Nawano; Nagahiro Saijo; Yutaka Nishiwaki |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-29 |
Journal Detail:
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Title: Lung cancer (Amsterdam, Netherlands) Volume: 57 ISSN: 0169-5002 ISO Abbreviation: Lung Cancer Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2007-12-14 Revised Date: 2008-02-25 |
Medline Journal Info:
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Nlm Unique ID: 8800805 Medline TA: Lung Cancer Country: Ireland |
Other Details:
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Languages: eng Pagination: 328-33 Citation Subset: IM |
Affiliation:
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Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwanoha 6-5-1, Kashiwa, Chiba 277-8577, Japan. siniho@east.ncc.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Small Cell / radionuclide imaging*, secondary* Female Fluorodeoxyglucose F18 / diagnostic use Humans Lung Neoplasms / pathology* Lymphatic Metastasis Male Middle Aged Neoplasm Staging Positron-Emission Tomography* Radiopharmaceuticals / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Erratum In:
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Lung Cancer. 2007 Dec;58(3):432 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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