Document Detail


Detection of tubercule antigen in cerebrospinal fluids by ELISA for diagnosis of tuberculous meningitis.
MedLine Citation:
PMID:  2128835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An Enzyme Linked Immunosorbent Assay (ELISA) was standardised to detect the presence of tubercule antigen in cerebrospinal fluids from patients with meningitis. CSF samples from clinically suspected cases of tuberculous meningitis, culture proven pyogenic meningitis and non-bacterial aseptic central nervous system (CNS) disorders were tested by ELISA to demonstrate its potential utility for routine diagnostic purpose. Tubercule antigen was detected in 73% cases of tuberculous meningitis and was absent in pyogenic and other non-bacterial CNS disorder cases. The test appears to be a promising approach for a definitive diagnosis of tuberculous meningitis.
Authors:
N Wagle; A Vaidya; S Joshi; S M Merchant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  57     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-06-28     Completed Date:  1991-06-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  679-83     Citation Subset:  IM    
Affiliation:
Microbiology Section, Bai Jerbai Wadia Hospital for Children, Parel, Bombay.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Bacterial / analysis*
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Humans
Mycobacterium tuberculosis / immunology*
Tuberculosis, Meningeal / cerebrospinal fluid,  diagnosis*,  immunology
Chemical
Reg. No./Substance:
0/Antigens, Bacterial

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