Document Detail


Detection of trisomy 18 by double screening in a low-risk pregnant population.
MedLine Citation:
PMID:  10072643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A combination of low concentrations of maternal serum alpha fetoprotein (MSAFP) and human chorionic gonadotropin (hCG) was used to screen for trisomy 18 in early 2nd-trimester pregnancies in a low-risk child-bearing population. METHODS: Women less than 37 years of age were offered screening between 15 and 20 weeks of gestation. Those pregnancies showing low concentrations of MSAFP (<0. 75 multiples of the median) and hCG (<0.5 multiples of the mean) were considered positive. If gestational age was confirmed, genetic counselling and invasive prenatal diagnosis were offered. RESULTS: Between January 1995 and December 1996, 19,491 women were screened, of whom 252 were found to be positive (1.25%). 145 invasive procedures were carried out, and 3 cases were detected. The odds of a fetus being affected after a positive screen result were 1 in 36. CONCLUSIONS: Measurement of low concentrations of MSAFP and hCG in pregnant women less than 37 years of age is an effective screening test for Edward's syndrome, but with regard to the natural history of this genetic condition, it can result in overuse of invasive tests which in turn can harm chromosomally normal pregnancies. This stresses the need to evaluate these pregnancies further with detailed ultrasonographic assessment and selective fetal karyotyping only.
Authors:
H Seppo; R Markku; N Marko; K Pertti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  14     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-05-19     Completed Date:  1999-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University Hospital of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Chromosomes, Human, Pair 18*
Female
Humans
Mass Screening / methods*
Pregnancy
Pregnancy Complications / blood,  diagnosis*
Risk Factors
Trisomy*
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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