Document Detail


Detection of squamous cell cancer and pre-cancerous lesions by imaging of tissue autofluorescence in the hamster cheek pouch model.
MedLine Citation:
PMID:  1341249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Early detection of invasive and pre-invasive neoplasms of the aerodigestive tract will ultimately improve the management of patients with these lesions. This paper describes the use of quantitative fluorescence imaging of early squamous cell carcinomas in an animal model. Dysplasia, carcinoma in situ and invasive cancers were imaged exploiting tumour autofluorescence. Mapped biopsies were obtained from areas imaged determining a sensitivity of 100% and specificity of 80%. Autofluorescence imaging is an excellent method of detecting neoplasms of the aerodigestive tract.
Authors:
A M Kluftinger; N L Davis; N F Quenville; S Lam; J Hung; B Palcic
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgical oncology     Volume:  1     ISSN:  0960-7404     ISO Abbreviation:  Surg Oncol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1994-01-13     Completed Date:  1994-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208188     Medline TA:  Surg Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, Vancouver General Hospital, British Columbia, Canada.
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene
Animals
Bronchoscopes
Carcinoma in Situ / chemically induced,  diagnosis*
Carcinoma, Squamous Cell / chemically induced,  diagnosis*
Cheek
Cricetinae
Diagnosis, Computer-Assisted / instrumentation
Disease Models, Animal
Fluorescence*
Male
Mesocricetus
Mouth Mucosa / pathology
Mouth Neoplasms / chemically induced,  diagnosis*
Precancerous Conditions / chemically induced,  diagnosis*
Sensitivity and Specificity
Chemical
Reg. No./Substance:
57-97-6/9,10-Dimethyl-1,2-benzanthracene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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