Document Detail

Detection of sputum Aspergillus galactomannan for diagnosis of invasive pulmonary aspergillosis in haematological patients.
MedLine Citation:
PMID:  19838867     Owner:  NLM     Status:  MEDLINE    
We investigated the diagnostic utility of Aspergillus galactomannan (GM) in sputum for diagnosis of invasive pulmonary aspergillosis (IPA) in haematologic patients and compared the results with those of bronchial lavage fluid (BLF) and serum. Patients were classified into 4 groups using modified European Organization for Research and Treatment of Cancer criteria: group A, proven IPA; group B, probable IPA; group C, possible IPA; group D, others. Groups A and B were considered the IPA group (n = 6); group D was considered non-IPA group (n = 37); group C (n = 13) was equivocal for IPA. As a true negative control, sputa from patients with community-acquired pneumonia (CAP) without risk factors (group E, n = 22) were used. From the receiver-operating characteristic curves, the cut-off levels were determined as 1.2 in sputum, 0.5-1.3 in BLF and 0.5 in serum. The sensitivity and specificity of sputum, BLF and serum GM were 100 and 62.2%, 66.7 and 100%, and 83.3 and 81.1%, respectively. Twenty-two patients with CAP (group E) showed median GM levels in the sputa of 0.1 (range 0.0-1.0). Sputum GM is a useful non-invasive test for screening of IPA in haematological patients, and may also be useful for assessment of the risk of developing IPA.
Shun-ichi Kimura; Jun Odawara; Takatoshi Aoki; Masayuki Yamakura; Masami Takeuchi; Kosei Matsue
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-10-20
Journal Detail:
Title:  International journal of hematology     Volume:  90     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-70     Citation Subset:  IM    
Division of Hematology/Oncology, Department of Medicine, Kameda General Hospital, 929 Higashi-chou, Kamogawa, Chiba 296-8602, Japan.
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MeSH Terms
Aged, 80 and over
Bronchoalveolar Lavage Fluid / chemistry
Early Diagnosis
Enzyme-Linked Immunosorbent Assay
Hematologic Diseases / complications*
Immunocompromised Host
Invasive Pulmonary Aspergillosis / complications,  diagnosis*,  immunology
Mannans / analysis*,  blood
Middle Aged
Risk Factors
Sensitivity and Specificity
Sputum / chemistry*
Young Adult
Reg. No./Substance:
0/Mannans; 11078-30-1/galactomannan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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