| Detection of skewed T-cell receptor V-beta gene usage in the peripheral blood of patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 9626994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ex vivo analysis of the T-cell receptor V-beta (TCRBV) gene usage by circulating T lymphocytes in Multiple Sclerosis (MS) patients may contribute to understanding disease pathogenesis. In the present study, TCRBV gene usage was analyzed in freshly collected unstimulated peripheral blood mononuclear cells (PBMC) isolated from 40 MS patients and 20 healthy controls. Nine patients presented abnormal repertoires, with expansion of one or more TCRBV segments. Among these patients, six presented expansion of TCRBV9 chain expression, three also having an expansion of TCRBV1, TCRBV11 and TCRBV22 segments. The most frequently observed TCRBV chain expansion, TCRBV9, was further analyzed and identified as polyclonal. Evaluation of clinical variables showed that median disease duration was shorter in patients with TCRBV gene expression abnormalities. Longitudinal evaluation of five patients with a skewed repertoire showed regression of expanded TCRBV chains expression to normal values. These data indicate that certain MS patients have abnormal TCRBV gene expression. Such abnormalities are caused by polyclonal expansions of T lymphocyte subpopulations that use the same TCRBV gene families, are unstable and preferentially observed early in the course of the disease. |
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Authors:
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B Gran; D Gestri; A Sottini; E Quiròs Roldàn; A Bettinardi; S Signorini; D Primi; C Ballerini; R Taiuti; L Amaducci; L Massacesi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 85 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-07-07 Completed Date: 1998-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 22-32 Citation Subset: IM |
Affiliation:
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Dept. of Neurological and Psychiatrical Sciences, University of Florence, Italy. bgran@box-b.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acid Sequence Female Gene Expression* / physiology Humans Immunogenetics Longitudinal Studies Male Middle Aged Molecular Sequence Data Monocytes / physiology Multiple Sclerosis / blood*, genetics* Nucleic Acid Heteroduplexes / genetics Receptors, Antigen, T-Cell, alpha-beta / genetics* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acid Heteroduplexes; 0/Receptors, Antigen, T-Cell, alpha-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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