| Detection of serum anticerebellar antibodies in patients with Miller Fisher syndrome. | |
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MedLine Citation:
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PMID: 10567821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed Western blot analysis to detect anticerebellar antibodies in the serum of patients with Miller Fisher syndrome (MFS). We studied 7 MFS patients, 6 Guillain-Barré syndrome (GBS) patients and 10 normal healthy persons as controls. Six MFS patients (86%) had IgG antibodies against mouse cerebellar protein, whereas 3 GBS patients (50%) and 4 healthy controls (40%) had antibodies. The mean number of antibodies in the serum of patient with MFS was 2.43, which was significantly more than that of GBS patients (mean 0.67) and healthy control (mean 0.70). This finding suggests variability and complexity of target in nervous systems that suffer aberrant immunity in MFS, and may also reflect the variability and heterogeneity of the pathogenesis of this syndrome. |
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Authors:
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A Inoue; C Koh; T Iwahashi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European neurology Volume: 42 ISSN: 0014-3022 ISO Abbreviation: Eur. Neurol. Publication Date: 1999 |
Date Detail:
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Created Date: 2000-01-27 Completed Date: 2000-01-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 230-4 Citation Subset: IM |
Copyright Information:
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Copyright 1999 S. Karger AG, Basel |
Affiliation:
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Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Adult Aged Autoantibodies / blood* Blotting, Western Case-Control Studies Cerebellum / immunology* Female Guillain-Barre Syndrome / immunology Humans Immunoglobulin G / immunology* Male Middle Aged Miller Fisher Syndrome / immunology*, therapy Plasmapheresis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Autoantibodies; 0/Immunoglobulin G |
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