Document Detail


Detection of serum anticerebellar antibodies in patients with Miller Fisher syndrome.
MedLine Citation:
PMID:  10567821     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed Western blot analysis to detect anticerebellar antibodies in the serum of patients with Miller Fisher syndrome (MFS). We studied 7 MFS patients, 6 Guillain-Barré syndrome (GBS) patients and 10 normal healthy persons as controls. Six MFS patients (86%) had IgG antibodies against mouse cerebellar protein, whereas 3 GBS patients (50%) and 4 healthy controls (40%) had antibodies. The mean number of antibodies in the serum of patient with MFS was 2.43, which was significantly more than that of GBS patients (mean 0.67) and healthy control (mean 0.70). This finding suggests variability and complexity of target in nervous systems that suffer aberrant immunity in MFS, and may also reflect the variability and heterogeneity of the pathogenesis of this syndrome.
Authors:
A Inoue; C Koh; T Iwahashi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European neurology     Volume:  42     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1999  
Date Detail:
Created Date:  2000-01-27     Completed Date:  2000-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM    
Copyright Information:
Copyright 1999 S. Karger AG, Basel
Affiliation:
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
Aged
Autoantibodies / blood*
Blotting, Western
Case-Control Studies
Cerebellum / immunology*
Female
Guillain-Barre Syndrome / immunology
Humans
Immunoglobulin G / immunology*
Male
Middle Aged
Miller Fisher Syndrome / immunology*,  therapy
Plasmapheresis
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Autoantibodies; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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