| Detection and separation of two serum factors responsible for depression of lymphocyte activity in pregnancy. | |
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MedLine Citation:
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PMID: 668204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies using the rosette inhibition test have demonstrated a depression of lymphocyte activity in pregnant mice which occurs as early as 6 hr after fertilization and persists until just before delivery. This depression of lymphocyte activity is induced by two serum factors, the relative contributions of which vary with the time of gestation. The first, a high molecular weight early pregnancy factor, appears within hours of fertilization and then slowly declines in activity as gestation proceeds. The second, a lower molecular weight substance which cross-reacts with antiserum to human chorionic gonadotrophin, appears after the formation of the trophoblast at 4--5 days and persists until parturition. |
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Authors:
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F M Clarke; H Morton; G J Clunie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 32 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-09-25 Completed Date: 1978-09-25 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 318-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies Chorionic Gonadotropin / pharmacology Female Immunosuppression Lymphocytes / immunology* Mice Pregnancy Pregnancy, Animal* Rosette Formation Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Chorionic Gonadotropin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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