| Detection of rifampicin-induced nephrotoxicity by N-acetyl-3-D-glucosaminidase activity. | |
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MedLine Citation:
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PMID: 1460703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the present study was to assess renal damage, if any, by non-invasive technique, viz NAG activity in urine and GFR in patients on continuous and intermittent rifampicin therapy. Eighty-four tuberculosis patients for cross-sectional study and six subjects for longitudinal study on antitubercular therapy and ten patients on withdrawal of rifampicin participated in the investigation; 13 leprosy patients intermittently treated with rifampicin were also included. Twenty-seven normal subjects served as controls. Rifampicin on continuous use resulted in a progressive increase in enzymuria with no change in GFR. An additive toxic effect was obvious in patients receiving streptomycin; when the treatment was withdrawn the urinary NAG activity stabilized within 15-21 days. However, patients receiving rifampicin intermittently did not show any evidence of renal damage. The results suggest that there is a need for monitoring renal damage, particularly on antitubercular therapy, when nephrotoxic agents are administered together. |
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Authors:
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B D Kumar; C E Prasad; K Krishnaswamy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of tropical medicine and hygiene Volume: 95 ISSN: 0022-5304 ISO Abbreviation: J Trop Med Hyg Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-13 Completed Date: 1993-01-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0406044 Medline TA: J Trop Med Hyg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 424-7 Citation Subset: IM |
Affiliation:
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Food and Drug Toxicology Research Centre, National Institute of Nutrition, Hyderabad, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylglucosaminidase
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urine* Adult Cross-Sectional Studies Drug Synergism Drug Therapy, Combination / adverse effects, therapeutic use Glomerular Filtration Rate Humans Kidney / drug effects*, enzymology, physiology Leprosy / drug therapy Middle Aged Prospective Studies Rifampin / adverse effects*, therapeutic use Streptomycin / adverse effects, therapeutic use Tuberculosis, Pulmonary / drug therapy |
| Chemical | |
Reg. No./Substance:
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13292-46-1/Rifampin; 57-92-1/Streptomycin; EC 3.2.1.52/Acetylglucosaminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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