| Detection of retroviruses in a calvaria of a young mouse. | |
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MedLine Citation:
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PMID: 16999203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During systematic examination of the development and growth of mouse calvariae, virus particles were detected electron microscopically. Mice, strain NMRI, were obtained from the breeder Harlan-Winkelmann (Borchem, Germany) and mated in the animal house. The area of the sagittal suture from day-18 foetuses and from different stages until day-26 pp as well as from adult mice was studied. In the calvaria of a day-21 pp mouse, type-C virus particles were found in the pericellular space of many, but not all osteogenic cells. The morphology of all viruses found resembled that of retroviruses; they were regular in size, spherical and showed a diameter of 100-120 nm. Budding of viruses from the osteocyte membrane occurred frequently. Also type-A particles were detected intracisternally within the rough endoplasmic reticulum. Budding of type-C virus particles, extracellular deposition of retroviruses and intracisternal formation of type-A particles occurred in the same cell. However, although examinations of 22 different individual calvariae were done, only one obtained from a day-21 pp mice was virus-positive. Most probably, this observation is due to an endogenous virus production. Several mouse strains bear provirus DNA in their genome; the mode of activation of which is unknown. Reports in the literature are rare. Nevertheless, virus-infected material may influence experimental approaches and may be dangerous for the people who work with such material. |
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Authors:
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Bernd Zimmermann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft Volume: 188 ISSN: 0940-9602 ISO Abbreviation: Ann. Anat. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-26 Completed Date: 2006-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963897 Medline TA: Ann Anat Country: Germany |
Other Details:
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Languages: eng Pagination: 415-9 Citation Subset: IM |
Affiliation:
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Zentrum für Anatomie, Institut für Vegetative Anatomie, Charité-Universitätsmedizin Berlin, Campus Mitte, Germany. bernd.zimmermann@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Mice Retroviridae / isolation & purification* Skull / growth & development, ultrastructure, virology* |
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