Document Detail

Detection of residual infarct-related coronary artery stenosis and multivessel disease after thrombolysis: comparison between myocardial contrast echocardiography and single photon emission computed tomography.
MedLine Citation:
PMID:  16644439     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Detection of residual infarct-related artery (IRA) stenosis and multivessel disease (MVD) after thrombolysis has important therapeutic and prognostic implications. Technetium 99m sestamibi single photon emission computed tomography (SPECT) is used for detection of flow-limiting coronary artery disease (CAD). Myocardial contrast echocardiography (MCE) is a new technique developed to assess CAD. We aimed to compare the relative accuracy of vasodilator stress MCE and SPECT for detection of IRA stenosis and MVD after acute myocardial infarction. METHODS: Accordingly, 72 patients underwent simultaneous MCE and SPECT 7 +/- 2 days after thromobolysis. Coronary angiography was performed in all patients. RESULTS: Of the 72 patients, 60 demonstrated significant myocardial viability of which 55 (92%) showed significant IRA stenosis (> 50%). MVD was present in 30 (42%) of the 72 patients. MCE was more accurate than SPECT for detection of both IRA stenosis (85% vs 62%, P = .02) and MVD (85% and 64%, P = .004). CONCLUSION: MCE was comparable to SPECT for the detection of IRA stenosis and MVD after thrombolysis.
Girish Dwivedi; Rajesh Janardhanan; Sajad Hayat; Roxy Senior
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  19     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-28     Completed Date:  2006-06-06     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
Department of Cardiovascular Medicine, Northwick Park Hospital, Middlesex, United Kingdom.
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MeSH Terms
Coronary Angiography
Coronary Stenosis / complications,  diagnosis*,  drug therapy*
Middle Aged
Myocardial Infarction / diagnosis*,  etiology,  prevention & control*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / diagnostic use
Thrombolytic Therapy*
Tomography, Emission-Computed, Single-Photon*
Treatment Failure
Treatment Outcome
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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