| Detection of residual infarct-related coronary artery stenosis and multivessel disease after thrombolysis: comparison between myocardial contrast echocardiography and single photon emission computed tomography. | |
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MedLine Citation:
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PMID: 16644439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Detection of residual infarct-related artery (IRA) stenosis and multivessel disease (MVD) after thrombolysis has important therapeutic and prognostic implications. Technetium 99m sestamibi single photon emission computed tomography (SPECT) is used for detection of flow-limiting coronary artery disease (CAD). Myocardial contrast echocardiography (MCE) is a new technique developed to assess CAD. We aimed to compare the relative accuracy of vasodilator stress MCE and SPECT for detection of IRA stenosis and MVD after acute myocardial infarction. METHODS: Accordingly, 72 patients underwent simultaneous MCE and SPECT 7 +/- 2 days after thromobolysis. Coronary angiography was performed in all patients. RESULTS: Of the 72 patients, 60 demonstrated significant myocardial viability of which 55 (92%) showed significant IRA stenosis (> 50%). MVD was present in 30 (42%) of the 72 patients. MCE was more accurate than SPECT for detection of both IRA stenosis (85% vs 62%, P = .02) and MVD (85% and 64%, P = .004). CONCLUSION: MCE was comparable to SPECT for the detection of IRA stenosis and MVD after thrombolysis. |
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Authors:
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Girish Dwivedi; Rajesh Janardhanan; Sajad Hayat; Roxy Senior |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 19 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-28 Completed Date: 2006-06-06 Revised Date: 2007-11-02 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 546-51 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Northwick Park Hospital, Middlesex, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Angiography Coronary Stenosis / complications, diagnosis*, drug therapy* Echocardiography* Female Humans Male Middle Aged Myocardial Infarction / diagnosis*, etiology, prevention & control* Prognosis Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Technetium Tc 99m Sestamibi / diagnostic use Thrombolytic Therapy* Tomography, Emission-Computed, Single-Photon* Treatment Failure Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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