Document Detail

Detection of the regression on hydroxychloroquine retinopathy in optical coherence tomography.
MedLine Citation:
PMID:  19221829     Owner:  NLM     Status:  MEDLINE    
Hydroxychloroquine (HCQ) that is widely used in the treatment of the connective tissue disorders can cause retinopathy. The fundus examination of a patient with systemic lupus erythematosus receiving HCQ revealed left incomplete bull's eye and pigmentary changes in macula in the right eye. Repeated visual field tests showed the paracentral and peripheral defects in the right eye and the pericentral ring scotoma in the left eye. Optical coherence tomography (OCT) scans revealed the photoreceptor loss, retina pigment epithelium (RPE) irregularities, and a cyst-like hypo reflective space over RPE layer on the nasal perifoveal region in the left eye. On the ophthalmoscopic examination, the perifoveal pigmentation was not altered after the discontinuation of HCQ. However, the bilateral visual field defects were improved and the photoreceptor destruction and cyst-like hyporeflective space disappeared in the left eye. Mild RPE irregularities remained in both eyes as revealed by OCT scans. Even if OCT is used to evaluate the regression of HCQ retinopathy, it only shows advanced stage of retinopathy.
Burak Turgut; Peykan Turkcuoglu; Süleyman Serdar Koca; Orhan Aydemir
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-02-17
Journal Detail:
Title:  Clinical rheumatology     Volume:  28     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  607-9     Citation Subset:  IM    
Department of Ophthalmology, Faculty of Medicine, Firat University, Elazig, Turkey.
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MeSH Terms
Antirheumatic Agents / adverse effects*
Hydroxychloroquine / adverse effects*
Lupus Erythematosus, Systemic / complications,  drug therapy
Ophthalmoscopy / methods
Retinal Diseases / chemically induced*,  diagnosis,  therapy*
Retinal Pigment Epithelium / pathology
Tomography, Optical Coherence / methods*
Treatment Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 118-42-3/Hydroxychloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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