Document Detail

Detection of regional myocardial dysfunction in patients with acute myocardial infarction using velocity vector imaging.
MedLine Citation:
PMID:  18356019     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Velocity vector imaging (VVI) is a new echocardiographic technique of measuring regional myocardial velocities and deformation. Our aim was to evaluate the feasibility and accuracy of VVI in defining regional functional abnormalities in patients with an acute myocardial infarction. METHODS: Standard echocardiography and delayed enhancement (DE) magnetic resonance imaging were performed in 32 patients (29 men, mean age 61.2 +/- 8.1 years) within 36 hours of primary angioplasty. Twenty healthy volunteers (16 men, mean age 34.6 +/- 6.3 years) served as control subjects. Using VVI for offline analysis, segmental longitudinal deformation indices were measured. Infarcted, adjacent, and remote left ventricular segments were defined according to DE magnetic resonance imaging and coronary angiography. Infarct transmurality was also graded based on the DE extent within each segment on DE magnetic resonance imaging (0%-25%, 26%-50%, 51%-75%, and >76% of wall thickness). RESULTS: As compared with remote segments, myocardial infarction segments had significantly lower longitudinal systolic strain (S) (-9.6% vs -14.6%, P < .0001), lower S rate (-0.75 vs -1.08 s(-1), P < .0001), and a higher postsystolic S index (21% vs 8.3%, P < .001). By receiver operating characteristic curve analysis, a myocardial peak systolic longitudinal S lower than -6.5% in at least one ventricular segment showed best predictive value (94%) for detecting an infarcted left ventricle. Peak systolic S and S rate were useful predictors of the presence of regional dysfunction, and for the localization and transmural extent of the infarct. CONCLUSIONS: VVI is a promising new tool for studying myocardial motion and deformation with good feasibility in the clinical setting. The assessment of myocardial longitudinal systolic S and S rate with VVI can be used to identify the presence, location, and the transmural extent of myocardial infarction.
Ruxandra Jurcut; Christos J Pappas; Pier Giorgio Masci; Lieven Herbots; Mariola Szulik; Jan Bogaert; Frans Van de Werf; Walter Desmet; Frank Rademakers; Jens-Uwe Voigt; Jan D'hooge
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-03-20
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  21     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  879-86     Citation Subset:  IM    
Department of Cardiovascular Diseases, Catholic University Leuven, Leuven, Belgium.
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MeSH Terms
Echocardiography / methods*
Elasticity Imaging Techniques / methods*
Feasibility Studies
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Myocardial Infarction / ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Ventricular Dysfunction, Left / ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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