Document Detail

Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death.
MedLine Citation:
PMID:  15576274     Owner:  NLM     Status:  MEDLINE    
AIMS: Maternal infections with parvovirus B19, cytomegalovirus (CMV) and enterovirus have been associated with intrauterine fetal death (IUFD), but the incidence of these infections is not clear. This prospective study was conducted to estimate this incidence. METHODS: A prospective study of 38 months was conducted on cases of IUFD referred to Huddinge University Hospital, Stockholm, Sweden. Placental biopsies, fetal blood and amniotic fluid were collected from cases of IUFD (n=52). Placental biopsies from normal pregnancies at term (n=53) were used as controls. These tissues were examined for parvovirus B19 DNA, CMV DNA and enterovirus RNA using polymerase chain reaction (PCR). Maternal viral serology was measured in 46 cases and virus isolation for enterovirus in maternal stool samples was performed in 31 cases. RESULTS: Viral nucleic acid was recovered in at least one tissue sample from six cases of fetal death (parvovirus B19 in two cases, CMV in three and enterovirus in one), while all placental biopsies from controls were found negative. Serological signs of primary maternal infection were found in two of the cases, and virus isolation for enterovirus was negative in all samples examined. CONCLUSION: Parvovirus B19, CMV and enterovirus may be considered as etiologic agents in cases of fetal death. PCR on placental and/or fetal tissue improves diagnostic accuracy for these infections.
Karin Petersson; Oscar Norbeck; Magnus Westgren; Kristina Broliden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  32     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2004  
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  516-21     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Huddinge, Sweden.
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MeSH Terms
Cytomegalovirus / genetics,  isolation & purification
Cytomegalovirus Infections / epidemiology
DNA, Viral / analysis
Enterovirus / genetics,  isolation & purification
Enterovirus Infections / epidemiology
Fetal Death
Parvoviridae Infections / epidemiology
Parvovirus B19, Human / genetics,  isolation & purification
Polymerase Chain Reaction
Pregnancy Complications, Infectious / epidemiology*,  etiology,  virology*
Prospective Studies
RNA, Viral / analysis
Sweden / epidemiology
Reg. No./Substance:
0/DNA, Viral; 0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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